INT244524

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 24
Disease Relevance 11.33
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
lung 2
A549 1
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 24 99.70 Very High Very High Very High
Nicotine 216 39.20 Quite Low
Inflammatory response 24 20.28 Low Low
Inflammation 120 5.00 Very Low Very Low Very Low
COX-2 inhibitor 24 5.00 Very Low Very Low Very Low
cINOD 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1608 99.82 Very High Very High Very High
Cancer 960 98.88 Very High Very High Very High
Lung Cancer 1128 97.92 Very High Very High Very High
Repression 24 97.52 Very High Very High Very High
Breast Cancer 72 96.60 Very High Very High Very High
Small Cell Lung Cancer 192 95.68 Very High Very High Very High
Malignant Neoplastic Disease 480 95.40 Very High Very High Very High
Disease 168 93.88 High High
Carcinoma 288 93.56 High High
Non-small-cell Lung Cancer 216 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon activation, PERK phosphorylates eIF2?
Phosphorylation (phosphorylates) of eIF2
1) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
Figure 10 shows that the thiol N-acetyl-L-cysteine (NAC), a potent free radical scavenging compound with antioxidant activity, can completely prevent CS-induced phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2
2) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
CS treatment induces the phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2
3) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0
The results shown in Figure 9 indicated that the vapor phase is as efficient as whole CS in inducing ER stress and the phosphorylation of eIF2?.
Phosphorylation (phosphorylation) of eIF2 associated with stress
4) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0
Figure 1, Panel A shows that exposure of NHBE to CS from 2R4F reference cigarettes resulted in the rapid phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2
5) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.22 Pain Relevance 0
As shown in Figure 2, PERK siRNA transfected A549 cells show notably reduced phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2 in A549
6) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0.04
The suppression of protein translation via phosphorylation of both PERK and eIF2?
Phosphorylation (phosphorylation) of eIF2
7) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0
Unlike the transcriptionally active ATF6 and XBP1 proteins, PERK, upon release from BiP/GRP78, undergoes autophosphorylation and activation of a kinase function that phosphorylates the alpha subunit of eIF2 (eukaryotic translation initiation factor 2) and a transient repression of global protein synthesis.
Phosphorylation (phosphorylates) of eIF2 associated with repression
8) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.46 Pain Relevance 0
Support for this hypothesis comes, in part, from the data presented in this study showing that CS causes ER stress and activates the UPR pathway via phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2 associated with stress
9) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.62 Pain Relevance 0
In addition to PERK, three other kinases capable of phosphorylating eIF2?
Phosphorylation (phosphorylating) of eIF2
10) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.21 Pain Relevance 0
Consequently, in order to show that CS treatment induces ER stress, it is important to demonstrate the dependence of CS-induced phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2 associated with stress and addiction
11) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0.05
when treated with CS (Panel A) or thapsigargin (Panel B), indicating that PERK is the major effector of CS-induced phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2
12) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.04
Thus, phosphorylation of eIF2?
Phosphorylation (phosphorylation) of eIF2
13) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.03
phosphorylation in diploid normal human bronchial epithelial (NHBE) lung cells as well as malignant human lung cells (A549) treated with a relatively brief exposure to whole smoke, we assessed the response of cells exposed to CS from 2R4F reference cigarettes as well as 'full-flavor' Brand A, 'lights' Brand B for the transient phosphorylation of eIF2?.
Phosphorylation (phosphorylation) of eIF2 in lung associated with malignant neoplastic disease
14) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.34 Pain Relevance 0
, phospho-eIF2?
Phosphorylation (phospho) of eIF2
15) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
, anti-phospho-eIF2?
Phosphorylation (phospho) of eIF2
16) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
cat#9722, phospho-eIF2?
Phosphorylation (phospho) of eIF2
17) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
, phospho-eIF2?
Phosphorylation (phospho) of eIF2
18) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.29 Pain Relevance 0
The anti-phospho-eIF2?
Phosphorylation (phospho) of eIF2
19) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.51 Pain Relevance 0
, phospho-eIF2?
Phosphorylation (phospho) of eIF2
20) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox