INT24453

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 13.70
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3) signal transduction (NLRP3) cytoplasm (NLRP3)
Anatomy Link Frequency
cavities 1
aorta 1
follicles 1
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 13 99.08 Very High Very High Very High
substance P 7 97.36 Very High Very High Very High
fibrosis 8 95.72 Very High Very High Very High
Inflammation 254 94.96 High High
Fibrositis 99 93.36 High High
addiction 11 84.40 Quite High
headache 8 83.60 Quite High
Arthritis 19 82.80 Quite High
Crohn's disease 5 81.04 Quite High
cINOD 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Syndrome 674 100.00 Very High Very High Very High
Pressure And Volume Under Development 78 99.72 Very High Very High Very High
Infection 70 99.24 Very High Very High Very High
INFLAMMATION 270 99.08 Very High Very High Very High
Familial Mediterranean Fever 30 98.92 Very High Very High Very High
Hypoxia 8 98.12 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 10 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 33 97.56 Very High Very High Very High
Disease 171 97.40 Very High Very High Very High
Diabetic Retinopathy 188 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First described in 1981, the association with the NLRP3 gene was found in 2002.7,8 However, only about 50% to 60% of patients have mutations in this gene.9
NLRP3 Binding (association) of
1) Confidence 0.48 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 3.00 Pain Relevance 0.29
This occurs in part as the result of interactions between vasoconstrictors, e.g., angiotensin II (AII), and the vasodilatory prostaglandins E2 or I2.
AII Binding (interactions) of
2) Confidence 0.48 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092664 Disease Relevance 0.13 Pain Relevance 0.13
Angiotensin II/III (AII/III), estradiol (E2) and progesterone concentrations increase with the size of the follicles.
AII Binding (increase) of in follicles
3) Confidence 0.36 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2459891 Disease Relevance 0 Pain Relevance 0.40
In addition, we examined NLRP3 (C1AS1 showed a single missense mutation in its exons) and 3 other genes associated with the inflammasome (ASC1, ASC2, and CD2BP1 exhibited no missense mutations in their exons).
NLRP3 Binding (associated) of
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.94 Pain Relevance 0.36
Monosodium urate (Martinon et al 2006), calcium pyrophosphate and silica crystals (Cassel et al 2008), aluminium hydroxide (a vaccine adjuvant) (Eisenbarth et al 2008), DNA fragments (Muruve et al 2008), ATP and potassium flux (Petrilli et al 2007) have all so far been identified as danger signals recognized by NALP3 in the context of infection and/or tissue damage.
NALP3 Binding (recognized) of associated with crystal associated disease and infection
5) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.25 Pain Relevance 0
Similar to that found with the Nalp1 and Nalp3 inflammasome components, variation of expression levels of these genes was lower than threefold among the PRK samples.
Nalp3 Binding (found) of
6) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.03
It has been proposed that these mutations have a gain of function effect, leading to spontaneous oligorimerization of NALP3 subunits around mutated NACHT domains and subsequent caspase-1 activation resulting in an excessive and inappropriate IL-1?
NALP3 Binding (oligorimerization) of
7) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.56 Pain Relevance 0
Mutations such as R260W, V198M, V262G can all, for example, result in MWS or FCAS (Dode et al 2002a), whilst on the other hand, Y570, F309SA and F523L are exclusively associated with severe forms of CINCA (Aksentijevich et al 2002).
FCAS Binding (associated) of associated with syndrome
8) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.10 Pain Relevance 0
Mutations such as R260W, V198M, V262G can all, for example, result in MWS or FCAS (Dode et al 2002a), whilst on the other hand, Y570, F309SA and F523L are exclusively associated with severe forms of CINCA (Aksentijevich et al 2002).
MWS Binding (associated) of associated with syndrome
9) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.10 Pain Relevance 0
Following ligand binding, which is thought but not proven to be via LRR domain, NALP3 undergoes NACHT domain-mediated self-oligomerization.
NALP3 Binding (binding) of
10) Confidence 0.31 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.25 Pain Relevance 0
due to heightened activity of the NLR family member NLRP3 (NALP3/cryopyrin; [3]).
NLRP3 Binding (activity) of
11) Confidence 0.29 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.46 Pain Relevance 0.19
Resonance-like interactions of MWs with such targets as cellular membranes, chromosomal DNA, and ions in protein cavities have been proposed (Adey 1999; Belyaev et al. 1992a; Binhi 2002; Ismailov 1987).
MWs Binding (interactions) of in cavities
12) Confidence 0.28 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.22 Pain Relevance 0.11
AII binds and
AII Binding (binds) of
13) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.85 Pain Relevance 0.07
Chicken aorta, unlike the aortae of any other species tested, did not respond to angiotensin II (AII) at concentrations up to 10(-4) M.
AII Neg (not) Binding (respond) of in aorta
14) Confidence 0.06 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 7268192 Disease Relevance 0 Pain Relevance 0
NALP3 forms an inflammasome complex with ASC, cardinal, and procaspase-1 [79].
NALP3 Binding (complex) of
15) Confidence 0.06 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.37 Pain Relevance 0.03
and is linked to AII-mediated induction of inflammatory mediators and growth
AII Binding (linked) of associated with inflammatory mediators
16) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.23 Pain Relevance 0.14
Furthermore, AT1 and AT2, AII, and its
AII Binding (its) of
17) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.16 Pain Relevance 0.09
AT1-R, leaving AII to interact with the relatively beneficial AT2-R.
AII Binding (interact) of
18) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.08 Pain Relevance 0.08

General Comments

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