INT244534

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ERN1) endoplasmic reticulum (ERN1)
Anatomy Link Frequency
thalamus 1
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 1 97.12 Very High Very High Very High
addiction 2 82.76 Quite High
Autonomic response 14 48.56 Quite Low
Pain 1 30.00 Quite Low
Somatosensory cortex 5 19.32 Low Low
Anterior cingulate cortex 1 17.76 Low Low
Nicotine 9 5.00 Very Low Very Low Very Low
insula 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 67 99.28 Very High Very High Very High
Death 3 98.52 Very High Very High Very High
Nicotine Addiction 30 94.16 High High
Attention Deficit Hyperactivity Disorder 1 82.20 Quite High
Autism 1 81.96 Quite High
Cognitive Disorder 10 76.96 Quite High
Adenocarcinoma 2 67.04 Quite High
Apoptosis 8 60.16 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Cancer 40 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lin et al have recently shown that IRE1 and ATF6 activities were attenuated by persistent ER stress in human cells resulting in increased cell death [61].
Negative_regulation (attenuated) of IRE1 associated with stress and death
1) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.84 Pain Relevance 0
In a group of patients with focal lesions of the thalamus we found significantly impaired error awareness in a flanker task (signaling rate, patients, 39.1 vs. controls 85.1%) accompanied by amplitude reduction of the ERN and Pe (Seifert et al. 2010).
Negative_regulation (reduction) of ERN in thalamus associated with thalamus
2) Confidence 0.08 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.24 Pain Relevance 0.09

General Comments

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