INT244535

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
respiratory tract 2
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 18 55.32 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 134 97.72 Very High Very High Very High
Nicotine Addiction 60 85.20 High High
Malignant Neoplastic Disease 40 50.00 Quite Low
Lung Cancer 94 5.00 Very Low Very Low Very Low
Cancer 80 5.00 Very Low Very Low Very Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Carcinoma 24 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 18 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since a primary constituent of the vapor phase of CS is a large amount of highly reactive organic and inorganic substances that either are free radicals or reactive species (such as •O2-, •NO, •OH, etc), and more stable organic reactive species/oxidants (such as phenols, hydroquinone, epoxides, etc.) that can cause a marked imbalance in an individual's redox state and an overall increase in oxidative stress in the respiratory tract [72-75], we were interested in determining if free radical scavengers could effectively suppress the induction of eIF2?
Negative_regulation (suppress) of Positive_regulation (induction) of eIF2 in respiratory tract associated with stress
1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
In contrast, the particulate phase appeared to be much less efficient at inducing eIF2?
Negative_regulation (efficient) of Positive_regulation (inducing) of eIF2
2) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

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