INT244537

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.32
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ERN1) endoplasmic reticulum (ERN1)
Anatomy Link Frequency
lung 1
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 10 95.56 Very High Very High Very High
Anterior cingulate cortex 2 94.00 High High
addiction 4 25.60 Quite Low
Autonomic response 28 5.00 Very Low Very Low Very Low
Nicotine 18 5.00 Very Low Very Low Very Low
insula 16 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
primary somatosensory cortex 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 134 99.48 Very High Very High Very High
Death 6 98.52 Very High Very High Very High
Nicotine Addiction 60 94.16 High High
Adenocarcinoma 4 67.04 Quite High
Apoptosis 16 60.16 Quite High
Malignant Neoplastic Disease 40 50.00 Quite Low
Blindness 16 43.40 Quite Low
Cancer 80 43.12 Quite Low
Autism 2 26.96 Quite Low
Lung Cancer 94 26.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lin et al have recently shown that IRE1 and ATF6 activities were attenuated by persistent ER stress in human cells resulting in increased cell death [61].
Regulation (attenuated) of IRE1 associated with stress and death
1) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.84 Pain Relevance 0
Effect of CS exposure on the IRE1 branch of UPR in normal human lung cells
Regulation (Effect) of IRE1 in lung
2) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.49 Pain Relevance 0
Note that in some studies modulations of the ERN and RCZ activity by error awareness was found (Maier et al. 2008; Harsay et al. 2010; Wessel et al. 2010), which contrasts with the common notion that the preconscious early correlates of error processing are not related to error awareness.
Regulation (modulations) of ERN
3) Confidence 0.06 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0 Pain Relevance 0.14
The discordant findings regarding ERN modulation may relate to statistical power.
Regulation (modulation) of ERN
4) Confidence 0.05 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0 Pain Relevance 0.11

General Comments

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