INT244552

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PPP1R15A) response to stress (PPP1R15A)
Anatomy Link Frequency
colon 1
PPP1R15A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 40.92 Quite Low
addiction 2 40.68 Quite Low
Inflammation 26 29.04 Quite Low
cytokine 50 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
Nicotine 18 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 99.56 Very High Very High Very High
Cancer 298 97.84 Very High Very High Very High
Apoptosis 65 95.12 Very High Very High Very High
Cold Sores 367 92.04 High High
Stress 136 88.76 High High
Glioma 11 85.68 High High
Lung Cancer 154 77.44 Quite High
Viral Infection 10 70.40 Quite High
Dna Damage 2 66.84 Quite High
Malignant Neoplastic Disease 46 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of colon cancer cell lines with 5-FU induced ATF3 along with other DNA damage response genes (GADD34, GADD45?
Positive_regulation (induced) of GADD34 in colon associated with colon cancer
1) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 1.01 Pain Relevance 0
CHOP and ATF3 in turn coordinate the upregulation of GADD34 which provides a feedback inhibitory effect on UPR [58].
Positive_regulation (upregulation) of GADD34
2) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.25 Pain Relevance 0
In addition, Figure 3 shows that both GADD34 (Panel B) and ATF3 (Panel C) protein levels also increase in CS-treated cells.
Positive_regulation (increase) of GADD34
3) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.22 Pain Relevance 0
Cisplatin significantly increased viral titer and resulted in a marked increase in GADD34 mRNA and protein expression.



Positive_regulation (increase) of GADD34
4) Confidence 0.14 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.97 Pain Relevance 0

General Comments

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