INT244559

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
A549 4
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 88.28 High High
Nicotine 36 5.00 Very Low Very Low Very Low
Inflammation 20 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 268 99.78 Very High Very High Very High
Malignant Neoplastic Disease 80 79.44 Quite High
Cancer 160 77.92 Quite High
Disease 28 77.24 Quite High
Apoptosis 32 54.56 Quite High
Lung Cancer 188 5.00 Very Low Very Low Very Low
Nicotine Addiction 120 5.00 Very Low Very Low Very Low
Hypoxia 48 5.00 Very Low Very Low Very Low
Carcinoma 48 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2, PERK siRNA transfected A549 cells show notably reduced phosphorylation of eIF2?
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of eIF2 in A549
1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0.04
The suppression of protein translation via phosphorylation of both PERK and eIF2?
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of eIF2
2) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.39 Pain Relevance 0
In addition to transiently suppressing protein translation during ER stress, a second function of PERK phosphorylation of eIF2?
Negative_regulation (function) of Phosphorylation (phosphorylation) of eIF2 associated with stress
3) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.42 Pain Relevance 0.04
As shown in Figure 2, PERK siRNA transfected A549 cells show notably reduced phosphorylation of eIF2?
Negative_regulation (show) of Phosphorylation (phosphorylation) of eIF2 in A549
4) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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