INT244562

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 26
Disease Relevance 23.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
lung 2
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 234 5.00 Very Low Very Low Very Low
Inflammation 130 5.00 Very Low Very Low Very Low
addiction 26 5.00 Very Low Very Low Very Low
COX-2 inhibitor 26 5.00 Very Low Very Low Very Low
cINOD 26 5.00 Very Low Very Low Very Low
Inflammatory response 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1742 100.00 Very High Very High Very High
Lung Cancer 1222 99.92 Very High Very High Very High
Malignant Neoplastic Disease 520 99.02 Very High Very High Very High
Cancer 1040 97.68 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 78 97.68 Very High Very High Very High
Small Cell Lung Cancer 208 97.04 Very High Very High Very High
Carcinoma 312 96.84 Very High Very High Very High
Non-small-cell Lung Cancer 234 95.90 Very High Very High Very High
Breast Cancer 78 95.36 Very High Very High Very High
Skin Cancer 130 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven of eight assessable cases of MCs (87.5%) showed a statistically significant increase in expression of eIF2?
Gene_expression (expression) of eIF2
1) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.14 Pain Relevance 0
Paradoxically, although our study showed that increased expression of eIF2?
Gene_expression (expression) of eIF2
2) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.14 Pain Relevance 0
Of the 94 assessable cases of NSCLCs, 57 (60.6%) showed a considerable increase in expression of eIF2?
Gene_expression (expression) of eIF2
3) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.33 Pain Relevance 0
Finally, we assessed whether there was any concordance in expression of eIF2?
Gene_expression (expression) of eIF2
4) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.13 Pain Relevance 0
Although our data support the conclusion that modulators of the UPR pathway are chronically impacted in this tumor type, aside from a modestly significant increase in BiP in the NSCLC diagnostic group with increasing age (p = 0.0187), we found no obvious correlation with any histopathological criteria such as gender, pathologic stage, histological type, or TMN-status and the increased expression of eIF2?
Gene_expression (expression) of eIF2 associated with non-small-cell lung cancer and cancer
5) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.42 Pain Relevance 0
Expression levels of eIF2?
Gene_expression (Expression) of eIF2
6) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.30 Pain Relevance 0
The EIF2 ?
Gene_expression (The) of EIF2
7) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.25 Pain Relevance 0
g/ml); c) a rabbit monoclonal anti-phospho-EIF2 antibody (Cell Signaling Technology cat.# 3597) recognizing Ser51 (used at 1:50 dilution and a concentration of 1 ?
Gene_expression (antibody) of EIF2
8) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.05 Pain Relevance 0
M), a potent inducer of ER stress and eIF2?
Gene_expression (stress) of eIF2 associated with stress
9) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.17 Pain Relevance 0
Both eIF2?
Gene_expression (Both) of eIF2
10) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.15 Pain Relevance 0
Rosenwald et al. have previously shown that eIF2?
Gene_expression (shown) of eIF2
11) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.38 Pain Relevance 0
g/ml); b) a mouse monoclonal anti-EIF2 antibody (Cell Signaling Technology cat. #2103) recognizing eIF2?
Gene_expression (antibody) of EIF2
12) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.18 Pain Relevance 0
The data indicate a statistically significant difference in expression of eIF2?
Gene_expression (expression) of eIF2
13) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.09 Pain Relevance 0
Furthermore, the activation of the UPR program via eIF2?
Gene_expression (program) of eIF2
14) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.36 Pain Relevance 0
The eIF2?
Gene_expression (The) of eIF2
15) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.11 Pain Relevance 0
and BiP (and possibly eIF2?)
Gene_expression (possibly) of eIF2
16) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.25 Pain Relevance 0
Representative immunohistochemical features of eIF2?
Gene_expression (features) of eIF2
17) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.25 Pain Relevance 0
Of greater clinical relevance, however, is that an immunohistochemical analysis of a human lung tumor tissue array containing 110 lung cancer specimens and 10 normal lung tissue controls from a total of 120 patients showed a statistically significant increase in the total levels of phospho-eIF2?
Gene_expression (phospho) of eIF2 in lung associated with lung cancer
18) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.13 Pain Relevance 0
M thapsigargin continuously for 72 h, BiP expression is still only seen after 24 hours post-treatment, indicating that BiP induction is a much later consequence of ER stress than is eIF2?
Gene_expression (stress) of eIF2 associated with stress
19) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
Expression of phospho-eIF2?
Gene_expression (Expression) of eIF2
20) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0

General Comments

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