INT244563

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 7.67
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
lung 2
lung epithelium 1
respiratory tract 1
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 14 85.92 High High
Nicotine 126 64.48 Quite High
Inflammation 70 5.00 Very Low Very Low Very Low
COX-2 inhibitor 14 5.00 Very Low Very Low Very Low
cINOD 14 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 938 100.00 Very High Very High Very High
Malignant Neoplastic Disease 280 99.26 Very High Very High Very High
Cancer 560 98.40 Very High Very High Very High
Lung Cancer 658 98.32 Very High Very High Very High
Skin Cancer 70 96.32 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 42 96.14 Very High Very High Very High
Small Cell Lung Cancer 112 95.16 Very High Very High Very High
Nicotine Addiction 420 94.36 High High
Non-small-cell Lung Cancer 126 93.44 High High
Adenocarcinoma 28 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, PERK-induced activation of eIF2?
Positive_regulation (activation) of eIF2
1) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.04
M), a potent inducer of ER stress and eIF2?
Positive_regulation (inducer) of eIF2 associated with stress
2) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.17 Pain Relevance 0
Since a primary constituent of the vapor phase of CS is a large amount of highly reactive organic and inorganic substances that either are free radicals or reactive species (such as •O2-, •NO, •OH, etc), and more stable organic reactive species/oxidants (such as phenols, hydroquinone, epoxides, etc.) that can cause a marked imbalance in an individual's redox state and an overall increase in oxidative stress in the respiratory tract [72-75], we were interested in determining if free radical scavengers could effectively suppress the induction of eIF2?
Positive_regulation (induction) of eIF2 in respiratory tract associated with stress
3) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
Thus, we assessed whether the fractionated vapor and particulate phases of CS from 2R4F cigarettes were also capable of inducing eIF2?
Positive_regulation (inducing) of eIF2
4) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0.03
Figure 9 shows that the vapor phase was as efficient at inducing eIF2?
Positive_regulation (inducing) of eIF2
5) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0.03
Since both BAs and SCCs are subgroups of NSCLCs that share the histological feature of being derived from lung epithelium [151], these data differ somewhat from ours which showed a statistically significant increase in eIF2?
Positive_regulation (increase) of eIF2 in lung epithelium associated with bronchiolo-alveolar adenocarcinoma and skin cancer
6) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.36 Pain Relevance 0
In contrast, the particulate phase appeared to be much less efficient at inducing eIF2?
Positive_regulation (inducing) of eIF2
7) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0.03
Indeed, treatment with both CS and thapsigargin appears to induce higher levels of eIF2?
Positive_regulation (levels) of eIF2
8) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.06 Pain Relevance 0
As previously observed for whole CS, there was no alteration in the total level of eIF2?
Positive_regulation (level) of eIF2
9) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0
Of the 93 assessable cases of NSCLCs, 52 (55.9%) showed a significant increase in expression of phospho-eIF2?
Positive_regulation (increase) of eIF2
10) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.21 Pain Relevance 0
However, in order to investigate PERK-dependent eIF2?
Positive_regulation (dependent) of eIF2
11) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0
M thapsigargin continuously for 72 h, BiP expression is still only seen after 24 hours post-treatment, indicating that BiP induction is a much later consequence of ER stress than is eIF2?
Positive_regulation (is) of eIF2 associated with stress
12) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
For example, we found that compared to non-malignant lung tissue, there is a significant increase in expression of phospho-eIF2?
Positive_regulation (increase) of eIF2 in lung associated with malignant neoplastic disease
13) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.18 Pain Relevance 0
Of greater clinical relevance, however, is that an immunohistochemical analysis of a human lung tumor tissue array containing 110 lung cancer specimens and 10 normal lung tissue controls from a total of 120 patients showed a statistically significant increase in the total levels of phospho-eIF2?
Positive_regulation (increase) of eIF2 in lung associated with lung cancer
14) Confidence 0.24 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.14 Pain Relevance 0

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