INT244566

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.69
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
lung 2
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 99.86 Very High Very High Very High
Nicotine 72 40.28 Quite Low
Inflammation 40 5.00 Very Low Very Low Very Low
COX-2 inhibitor 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 536 100.00 Very High Very High Very High
Lung Cancer 376 96.88 Very High Very High Very High
Cancer 320 95.04 Very High Very High Very High
Disease 56 94.36 High High
Malignant Neoplastic Disease 160 86.44 High High
Nicotine Addiction 240 70.16 Quite High
Apoptosis 64 30.00 Quite Low
Hypoxia 96 5.00 Very Low Very Low Very Low
Carcinoma 96 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 72 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
when treated with CS (Panel A) or thapsigargin (Panel B), indicating that PERK is the major effector of CS-induced phosphorylation of eIF2?
Positive_regulation (-) of Phosphorylation (phosphorylation) of eIF2
1) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.04
Figure 1, Panel A shows that exposure of NHBE to CS from 2R4F reference cigarettes resulted in the rapid phosphorylation of eIF2?
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of eIF2
2) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.27 Pain Relevance 0
Figure 10 shows that the thiol N-acetyl-L-cysteine (NAC), a potent free radical scavenging compound with antioxidant activity, can completely prevent CS-induced phosphorylation of eIF2?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2
3) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
Upon activation, PERK phosphorylates eIF2?
Positive_regulation (activation) of Phosphorylation (phosphorylates) of eIF2
4) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
The results shown in Figure 9 indicated that the vapor phase is as efficient as whole CS in inducing ER stress and the phosphorylation of eIF2?.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of eIF2 associated with stress
5) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0
Consequently, in order to show that CS treatment induces ER stress, it is important to demonstrate the dependence of CS-induced phosphorylation of eIF2?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2 associated with stress and addiction
6) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0.05
CS treatment induces the phosphorylation of eIF2?
Positive_regulation (induces) of Phosphorylation (phosphorylation) of eIF2
7) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0
The data presented above indicate that in vitro exposure of lung cells to CS induces the phosphorylation of eIF2?
Positive_regulation (induces) of Phosphorylation (phosphorylation) of eIF2 in lung
8) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.39 Pain Relevance 0

General Comments

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