INT244571

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (HERPUD1) molecular_function (HERPUD1) response to stress (HERPUD1)
HERPUD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 12 99.80 Very High Very High Very High
withdrawal 58 84.76 Quite High
tolerance 2 19.56 Low Low
Nicotine 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Failure 48 98.60 Very High Very High Very High
Renal Disease 2 90.00 High High
Death 17 82.76 Quite High
Stress 67 50.00 Quite Low
Malignant Neoplastic Disease 26 50.00 Quite Low
Sepsis 2 23.00 Low Low
Necrosis 2 22.16 Low Low
Pressure And Volume Under Development 4 21.84 Low Low
Frailty 2 21.36 Low Low
Weight Gain 2 20.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The only XBP1 specific genes that showed an increase upon CS exposure were ERdj4 (DNAJB9) and HERPUD1, which increased 4-fold and 2.5-fold, respectively, over their expression levels in mock-treated cells at four hours post-exposure.
Positive_regulation (increased) of HERPUD1
1) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
Antithymocyte globulin was given for induction and MMF/CSA were given as maintenance regimen.
Positive_regulation (induction) of MMF
2) Confidence 0.00 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.05 Pain Relevance 0.23
They randomized 1645 renal transplant recipients to receive standard-dose CSA, MMF and corticosteroids, or daclizumab induction, MMF and corticosteroids in combination with low-dose CSA, or low-dose TAC, or low-dose SRL.
Positive_regulation (induction) of MMF associated with corticosteroid and renal failure
3) Confidence 0.00 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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