INT24458

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.50
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 99.84 Very High Very High Very High
noradrenaline 9 99.68 Very High Very High Very High
Enkephalin 1 98.14 Very High Very High Very High
Clonidine 1 97.74 Very High Very High Very High
Pain 9 95.28 Very High Very High Very High
Kinase C 9 85.44 High High
addiction 2 82.68 Quite High
Nerve growth factor 5 79.48 Quite High
Neurotransmitter 5 77.44 Quite High
Neuropeptide 8 74.24 Quite High
Disease Link Frequency Relevance Heat
Bone Disease 135 100.00 Very High Very High Very High
Syndrome 11 99.48 Very High Very High Very High
Frontotemporal Dementia 2 98.88 Very High Very High Very High
Muscle Disease 2 96.96 Very High Very High Very High
Infection 3 96.40 Very High Very High Very High
Pain 8 95.28 Very High Very High Very High
Osteolysis 4 86.88 High High
Disease 30 80.76 Quite High
Stress 30 80.04 Quite High
Osteogenic Sarcomas 13 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stereochemistry of the theoretical model of N-gal was done by subjecting it into energy minimization in SwissPDB Viewer.
Negative_regulation (minimization) of PDB
1) Confidence 0.41 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0 Pain Relevance 0.07
The ALDH gene superfamily has been characterized in several organisms [8], and the crystallographic structural coordinates of selected ALDHs have been deposited in the Protein Database (PDB) [28].
Negative_regulation (deposited) of PDB
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.38 Pain Relevance 0.03
DNA analysis for the p62/SQSTM1 gene mutation was performed in all affected familial members and in several unaffected subjects, to evaluate the segregation of the M404V mutation with the PDB phenotype and to detect potentially asymptomatic gene carriers.
Negative_regulation (segregation) of PDB associated with bone disease
3) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 1.01 Pain Relevance 0.04
In the presence of either clonidine or [Leu5]enkephalin, which by themselves inhibited the electrically stimulated release of [3H]NA, the effect of PDB was significantly reduced.
Negative_regulation (reduced) of PDB associated with noradrenaline, enkephalin and clonidine
4) Confidence 0.24 Published 1987 Journal Life Sci. Section Abstract Doc Link 2882398 Disease Relevance 0 Pain Relevance 0.57
The mental summary score was only slightly reduced, to 48.7 +/- 11.8, in PDB; but this was statistically significant (P < 0.001).
Negative_regulation (reduced) of PDB associated with bone disease
5) Confidence 0.22 Published 2007 Journal Calcif. Tissue Int. Section Abstract Doc Link 17205328 Disease Relevance 0.98 Pain Relevance 0.10
In contrast, the PDB-induced decrease in Na and Cl absorption was not dependent on metabolites of the cyclooxygenase pathway, not dependent on extracellular Ca2+, and not blocked by tetrodotoxin.
Negative_regulation (decrease) of PDB associated with tetrodotoxin
6) Confidence 0.11 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3094382 Disease Relevance 0 Pain Relevance 0.28
The effects of PDB and PMB were not reduced by tetrodotoxin.
Neg (not) Negative_regulation (reduced) of PDB associated with tetrodotoxin
7) Confidence 0.08 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2460359 Disease Relevance 0 Pain Relevance 0.36
Molecular defects in PDB and related syndromes
Negative_regulation (defects) of PDB associated with syndrome and bone disease
8) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 2.13 Pain Relevance 0.07

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