INT24459

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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.00
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 96.56 Very High Very High Very High
noradrenaline 2 93.28 High High
tetrodotoxin 1 86.88 High High
Kinase C 4 86.32 High High
Pain 7 84.88 Quite High
Neurotransmitter 2 83.28 Quite High
Hippocampus 5 45.12 Quite Low
Osteoarthritis 2 34.48 Quite Low
rheumatoid arthritis 4 22.20 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 153 100.00 Very High Very High Very High
Syndrome 20 100.00 Very High Very High Very High
Osteoporosis 13 99.44 Very High Very High Very High
Infection 3 99.18 Very High Very High Very High
Measles 1 98.86 Very High Very High Very High
Viral Infection 1 97.84 Very High Very High Very High
Congenital Anomalies 5 97.68 Very High Very High Very High
Muscle Disease 15 96.08 Very High Very High Very High
Dementia 4 93.28 High High
Disease 162 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This has led to the suggestion that environmental factors such as measles virus infection might interact with SQSTM1 mutations to cause PDB [11].
Positive_regulation (cause) of PDB associated with measles, bone disease and infection
1) Confidence 0.46 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2442429 Disease Relevance 1.33 Pain Relevance 0
The Protein Data Bank (http://www.rcsb.org/pdb) accession number for the bovine RH crystal structure is 1f88A.



Positive_regulation (number) of pdb
2) Confidence 0.10 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1364505 Disease Relevance 0 Pain Relevance 0
NA release was evoked by pulses of either high K+ or Ca2+ (in the presence of high K+), or by electrical field stimulation. 4 beta-Phorbol 12,13-dibutyrate (PDB) increased and polymyxin B (PMB) reduced the K+-evoked NA release independent of the K+ concentration used for depolarization.
Positive_regulation (increased) of PDB
3) Confidence 0.09 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2460359 Disease Relevance 0 Pain Relevance 0.30
Mutations of the sequestosome 1 gene (SQSTM1), which encodes an important scaffold protein in the NFkappaB pathway, are a common cause of classical PDB.
Positive_regulation (cause) of PDB associated with bone disease
4) Confidence 0.06 Published 2006 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 16932700 Disease Relevance 1.69 Pain Relevance 0.06
PDB is caused by excessive osteoclastic activity and susceptibility to deformities like bowing and fractures.
Positive_regulation (caused) of PDB associated with congenital anomalies, osteoporosis and bone disease
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.75 Pain Relevance 0.08
Signalling pathway affected in PDB and related syndromes
Positive_regulation (syndromes) of PDB associated with syndrome and bone disease
6) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.68 Pain Relevance 0.05
Positional cloning studies have shown that FEO, ESH, and early-onset familial PDB are each caused by different mutations in the receptor activator of NF-?
Positive_regulation (caused) of PDB associated with bone disease
7) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.56 Pain Relevance 0

General Comments

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