INT24460

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Context Info
Confidence 0.73
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.96
Pain Relevance 6.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
neurons 2
trigeminal ganglion 1
striatum 1
globus pallidus 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 91 100.00 Very High Very High Very High
dopamine receptor 12 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
Pain 3 99.82 Very High Very High Very High
adenocard 1 99.64 Very High Very High Very High
trigeminal ganglion 6 98.96 Very High Very High Very High
Potency 2 98.96 Very High Very High Very High
Lamotrigine 23 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 98.52 Very High Very High Very High
Manic Depressive Disorder 125 96.76 Very High Very High Very High
Pressure Volume 2 Under Development 5 89.04 High High
Heart Rate Under Development 6 88.00 High High
Alcohol Addiction 150 85.80 High High
Bordatella Infection 1 82.64 Quite High
Hypertension 1 79.12 Quite High
Depression 17 75.00 Quite High
Cancer 3 72.52 Quite High
Adverse Drug Reaction 6 34.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum.
Localization (co-localization) of dopamine D2 in striatum associated with dopamine and opioid receptor
1) Confidence 0.73 Published 2004 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Title Doc Link 15224400 Disease Relevance 0 Pain Relevance 0.55
The aim of this study was to determine if dopamine D2 receptors (D2r) and micro-opioid receptors (microOr) are localized to the same neurons in the dorsolateral striatum.
Localization (localized) of dopamine D2 in neurons associated with dopamine and opioid receptor
2) Confidence 0.73 Published 2004 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 15224400 Disease Relevance 0 Pain Relevance 0.51
Neville et al. [44] determined that the DRD2 TaqI A is actually located not within DRD2, but rather within a protein-coding region, exon 8, of the adjacent ANKK1 gene.
Neg (not) Localization (located) of DRD2
3) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.63 Pain Relevance 0.39
Neville et al. [44] determined that the DRD2 TaqI A is actually located not within DRD2, but rather within a protein-coding region, exon 8, of the adjacent ANKK1 gene.
Neg (not) Localization (located) of DRD2
4) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.63 Pain Relevance 0.39
The effects of DL-tetrahydropalmatine (THP; a main active substance of the Chinese herb corydalis), haloperidol (a dopamine D2 receptor antagonist), apomorphine and amphetamine on cardiovascular function and striatal dopamine (DA) release were compared in rats under general anesthesia.
Localization (release) of dopamine D2 receptor associated with anesthesia, dopamine and antagonist
5) Confidence 0.61 Published 1995 Journal Pharmacology Section Abstract Doc Link 8577817 Disease Relevance 0.73 Pain Relevance 0.41
Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion.
Localization (localization) of dopamine D2 receptor in trigeminal ganglion associated with ganglion cysts, pain, dopamine and trigeminal ganglion
6) Confidence 0.56 Published 1995 Journal Anesth. Analg. Section Title Doc Link 7486101 Disease Relevance 0.38 Pain Relevance 0.59
Sections from the globus pallidus were used for the autoradiographic localization of D2 dopamine and A2a adenosine receptors.
Localization (localization) of D2 dopamine in globus pallidus associated with adenocard and dopamine
7) Confidence 0.23 Published 1994 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7621502 Disease Relevance 0 Pain Relevance 0.46
As for LTG, evidence for association with treatment response has thus far been reported for DRD2, ?
Localization (reported) of DRD2 associated with lamotrigine
8) Confidence 0.22 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.29 Pain Relevance 0.13
To block the actions of dopamine released by hypothalamic neurons, D1 and D2 dopamine receptor antagonists were used.
Localization (released) of D2 dopamine receptor in neurons associated with dopamine, antagonist and dopamine receptor
9) Confidence 0.18 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8985891 Disease Relevance 0.07 Pain Relevance 1.32
Both drugs reversed with similar potency the inhibition by LY 171555 of electrically evoked release of [3H]dopamine (a presynaptic dopamine-D2 effect).
Localization (release) of dopamine-D2 associated with dopamine and potency
10) Confidence 0.17 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2460616 Disease Relevance 0 Pain Relevance 0.54
The D2 dopaminergic receptor agonist, quinpirole, at 100 nM completely blocked PRL secretion induced by 20 mM TEA.
Localization (secretion) of D2 dopaminergic receptor associated with agonist
11) Confidence 0.16 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7489818 Disease Relevance 0.22 Pain Relevance 0.56
In in vitro superfusion experiments, risperidone and haloperidol reversed at nanomolar concentrations the inhibition by LY 171555 (a dopamine-D2 agonist) and by amphetamine of potassium and electrically evoked release of [3H]acetylcholine from striatal slices (postsynaptic dopamine-D2 effects).
Localization (release) of dopamine-D2 associated with dopamine and agonist
12) Confidence 0.15 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2460616 Disease Relevance 0 Pain Relevance 0.61

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