INT244605

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (BASP1) cytoskeleton (BASP1) nucleus (BASP1)
cytoplasm (BASP1)
Anatomy Link Frequency
brain 3
BASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 9.20 Low Low
backache 56 5.00 Very Low Very Low Very Low
Osteoarthritis 21 5.00 Very Low Very Low Very Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 16 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Neurodegenerative Disease 1 100.00 Very High Very High Very High
Sprains And Strains 11 81.24 Quite High
Osteoporosis 5 66.40 Quite High
Chordoma 7 38.12 Quite Low
Low Back Pain 56 5.00 Very Low Very Low Very Low
Osteoarthritis 28 5.00 Very Low Very Low Very Low
Hypoxia 14 5.00 Very Low Very Low Very Low
Adhesions 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in human AF cells the levels of BASP1 expression were closer to those of AC cells than NP cells.
Gene_expression (expression) of BASP1
1) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Expression of a subset of the validated bovine markers genes (KRT8, 18, 19 SNAP25, CDH2, TNMD, BASP1, FOXF1, IBSP and FBLN 1) was analysed in human cells.
Spec (analysed) Gene_expression (Expression) of BASP1
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell.
Gene_expression (expression) of BASP1 in brain associated with necrosis and cancer
3) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.20 Pain Relevance 0
The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell.
Gene_expression (attached) of signal protein 1 in brain associated with necrosis and cancer
4) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.20 Pain Relevance 0
The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell.
Gene_expression (attached) of BASP1 in brain associated with necrosis and cancer
5) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.20 Pain Relevance 0
Analysis of the IVD-specific marker genes (TNMD, BASP1, TNFAIP6, FOXF1 and FOXF2; Figure 3b) confirmed the microarray results, with expression being significantly higher in both NP and AF cells than AC cells (all genes P < 0.0001).
Gene_expression (expression) of BASP1
6) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Eleven genes (SNAP25, KRT8, KRT18, KRT19, CDH2, IBSP, VCAN, TNMD, BASP1, FOXF1 & FBLN1) were also differentially expressed in normal human NP cells, although to a lesser degree.
Gene_expression (expressed) of BASP1
7) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Finally, our gene set contains markers for a range of different cell differentiation fates, including embryonic development (AMD1, SERPINH1), vasculogenesis (S100A4), hematopoesis (B2M, IGFBP6, IKZF5), neurogenesis (BASP1, SERPINH1), and even osteoclastogenesis (CTSB, CTSD, CTSK); it is possible that these genes are downregulated in response to our osteogenic stimulus.
Gene_expression (neurogenesis) of BASP1 associated with neurodegenerative disease
8) Confidence 0.40 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2527292 Disease Relevance 0.33 Pain Relevance 0

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