INT24464

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Context Info
Confidence 0.29
First Reported 1981
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0.52
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlst) plasma membrane (Dlst) nucleus (Dlst)
transferase activity, transferring acyl groups (Dlst) cytoplasm (Dlst)
Anatomy Link Frequency
MCF-7 2
uterus 1
cranial nerve X 1
uterine 1
Dlst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
Morphine 9 99.80 Very High Very High Very High
midbrain 1 96.00 Very High Very High Very High
Potency 12 86.76 High High
medulla 1 86.08 High High
agonist 10 84.72 Quite High
antagonist 6 84.08 Quite High
opioid receptor 2 81.08 Quite High
opiate 1 48.48 Quite Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 5 97.08 Very High Very High Very High
Rickets 1 77.96 Quite High
Cancer 12 57.20 Quite High
Stroke 1 55.44 Quite High
Myocardial Infarction 1 54.96 Quite High
Disease 1 33.92 Quite Low
Aging 1 32.64 Quite Low
Osteoporosis 1 28.88 Quite Low
Hot Flashes 2 27.00 Quite Low
Breast Cancer 3 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Marked differences were found between the results obtained using tritiated E2, tritiated naloxone, and [(35)S]GTPgammaS binding, indicating the possible involvement of multiple binding sites.
E2 Binding (binding) of associated with narcan
1) Confidence 0.29 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11779147 Disease Relevance 0 Pain Relevance 0.35
Some of the modified peptides partially inhibited, while YPF-benzyl-allyl-amide fully inhibited, the E2 or [d-Ala(2),MePhe(4),Gly(5)ol]enkephalin stimulated [(35)S]GTPgammaS binding.
E2 Binding (binding) of associated with enkephalin
2) Confidence 0.29 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11779147 Disease Relevance 0 Pain Relevance 0.34
E2 binds to both receptors with apparently no difference in affinity, and recent binding assays showed that GEN had a higher affinity to ER-?
E2 Binding (binds) of
3) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.52 Pain Relevance 0.04
With extension of the E2 exposure period from 2 to 4 days, the synergistic interaction between E2 and morphine persisted for the negative, but not the positive, feedback action on LH.
E2 Binding (interaction) of associated with morphine
4) Confidence 0.23 Published 1987 Journal Endocrinology Section Abstract Doc Link 3032570 Disease Relevance 0 Pain Relevance 0.65
After adjusting the data, it is clear that major alterations in gene profiles were induced by estrogenic compounds, such as E2, DES, OP, and NP, and that these differences could have a significant effect on uterine function in reproductive tissues during the estrous cycle.
E2 Spec (clear) Binding (compounds) of in uterine
5) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
Treatments with OP and NP inhibited the binding affinity of E2 to ER in MCF-7 cells by a competitive ER binding assay [18].
E2 Binding (binding) of in MCF-7
6) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.14
Treatments with OP and NP inhibited the binding affinity of E2 to ER in MCF-7 cells by a competitive ER binding assay [18].
E2 Binding (affinity) of in MCF-7
7) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.14
The interaction between E2 and P4 on proenkephalin gene expression in the uterus varied with species.
E2 Binding (interaction) of in uterus
8) Confidence 0.07 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2460751 Disease Relevance 0 Pain Relevance 0
Immunoreactive cell bodies were found in the telencephalon, diencephalon, and mesencephalon in areas as yet uncharacterized as discrete nuclei in birds (E-1, E-2, E-3, E-4, E-5); further cells were located in the diencephalic nucleus spiriformis lateralis, the midbrain medial intercollicular nucleus (E-6), the nucleus mesencephalicus lateralis, pars dorsalis, the Edinger-Westphal nucleus and dorsal occulomotor nucleus; and in the nucleus of cranial nerve X and an uncharacterized area in the dorsolateral medulla (E-7).
E-2 Binding (birds) of in cranial nerve X associated with medulla and midbrain
9) Confidence 0.02 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 7024329 Disease Relevance 0 Pain Relevance 0.34

General Comments

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