INT244677

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 9.54
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp16) extracellular region (Mmp16) proteinaceous extracellular matrix (Mmp16)
plasma membrane (Mmp16)
Anatomy Link Frequency
lung 14
Mmp16 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 225 99.92 Very High Very High Very High
fibrosis 25 92.12 High High
metalloproteinase 256 75.00 Quite High
Kinase C 4 51.80 Quite High
dorsal root ganglion 78 50.00 Quite Low
Pain 18 25.52 Quite Low
Neuropathic pain 66 18.76 Low Low
Inflammation 10 5.52 Low Low
anesthesia 25 5.00 Very Low Very Low Very Low
Eae 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 164 100.00 Very High Very High Very High
Bronchopulmonary Dysplasia 1525 99.84 Very High Very High Very High
Hyperoxia 175 99.66 Very High Very High Very High
Pulmonary Disease 100 97.12 Very High Very High Very High
Birth Weight 125 94.24 High High
Disease 50 93.28 High High
Pulmonary Fibrosis 25 92.12 High High
Genetic Predisposition To Disease 75 85.52 High High
Growth Disorder 50 69.92 Quite High
Ganglion Cysts 82 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further evaluation of MMP16 expression during the course of normal human and rat lung development showed relatively low expression during the canalicular and saccular stages and a clear increase in both mRNA and protein levels during the alveolar stage.
Gene_expression (expression) of MMP16 in lung
1) Confidence 0.73 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2527515 Disease Relevance 0.48 Pain Relevance 0.10
MMP16 protein expression was also determined in lung tissue from eight deceased fetuses without lung disease, sampled between 13 and 35 weeks of pregnancy (Figure 3A).
Spec (determined) Gene_expression (expression) of MMP16 protein in lung associated with pulmonary disease
2) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.27 Pain Relevance 0
MMP16 expression in rat lung
Gene_expression (expression) of MMP16 in lung
3) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.09 Pain Relevance 0
Effects of hyperoxia and dexamethasone on MMP16 gene expression in postnatal rat lung
Gene_expression (expression) of MMP16 gene in lung associated with hyperoxia and dexamethasone
4) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.25 Pain Relevance 0.13
Then, lung MMP16 gene expression peaks on day 14 and remains elevated until day 24 of life, before falling to very low levels in adulthood.
Gene_expression (expression) of MMP16 gene in lung
5) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.17 Pain Relevance 0.04
The different expression profiles of MMP14 and MMP16 suggest primary involvement of the former in the first step and of the latter in the whole process, including the second step.
Gene_expression (expression) of MMP16
6) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.05 Pain Relevance 0.03
In addition, MMP16 gene expression was high during normal newborn rat lung alveolarization, and was markedly reduced by insults that arrested alveolarization.
Gene_expression (expression) of MMP16 gene in lung
7) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.87 Pain Relevance 0.06
MMP16 is known to be expressed in the human lung [10].
Gene_expression (expressed) of MMP16 in lung
8) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.18 Pain Relevance 0.04
In newborn rats, lung MMP16 gene expression is low during the canalicular and saccular stages, and increases significantly very close to the beginning of alveolarization, i.e. postnatal day 4 [26].
Gene_expression (expression) of MMP16 gene in lung
9) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.18 Pain Relevance 0.05
Apparent discrepancies between changes in MMP16 expression in BPD infants and changes in animal models of arrested alveolarization may be due to differences in time frame.
Gene_expression (expression) of MMP16 associated with bronchopulmonary dysplasia
10) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.37 Pain Relevance 0
MMP16 protein expression in rat lung ran parallel to MMP16 gene expression, with a gradual increase in both the presumed transmembrane and soluble forms during alveolarization, and strong expression on day 21.
Gene_expression (expression) of MMP16 gene in lung
11) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.15 Pain Relevance 0.04
Thus, in both BPD infants and animal models, altered distal lung development is associated to opposite changes in MMP16 expression as those normally observed in the corresponding lung development stage.
Gene_expression (expression) of MMP16 in lung associated with bronchopulmonary dysplasia
12) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.47 Pain Relevance 0
MMP16 protein expression in rat lung ran parallel to MMP16 gene expression, with a gradual increase in both the presumed transmembrane and soluble forms during alveolarization, and strong expression on day 21.
Gene_expression (expression) of MMP16 protein in lung
13) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.16 Pain Relevance 0.04
We found that the pulmonary MMP16 expression profile differed from that of MMP14 in lung fibroblasts from newborn rats.
Gene_expression (expression) of MMP16 in lung
14) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0 Pain Relevance 0
We found that hyperoxia and dexamethasone, both of which impair alveolarization, strongly reduced lung MMP16 gene expression in newborn rats.
Gene_expression (expression) of MMP16 gene in lung associated with hyperoxia and dexamethasone
15) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.36 Pain Relevance 0.05
Animal experiments are models of arrested alveolar septation, a stage associated to a strong physiological increase in MMP16 expression.
Gene_expression (expression) of MMP16
16) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.42 Pain Relevance 0
Expression profile of MMP16 mRNA and protein from fetal life to adulthood
Gene_expression (profile) of MMP16 mRNA
17) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.09 Pain Relevance 0
Given this association between the MMP16 genotype and MMP2 activation, we used immunoblot to determine MMP16 protein content in supernatants of tracheal aspirates from infants with homogenous genotypes, namely GG and TT (n?
Gene_expression (genotype) of MMP16
18) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.34 Pain Relevance 0
Given this association between the MMP16 genotype and MMP2 activation, we used immunoblot to determine MMP16 protein content in supernatants of tracheal aspirates from infants with homogenous genotypes, namely GG and TT (n?
Spec (determine) Gene_expression (content) of MMP16 protein
19) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.33 Pain Relevance 0
In newborn rats exposed to hyperoxia for 7 days, the MMP16 gene expression level (Figure 4A) was about 60% lower than in controls.
Gene_expression (expression) of MMP16 gene associated with hyperoxia
20) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.25 Pain Relevance 0.17

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