INT244704

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 65
Total Number 67
Disease Relevance 37.74
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARG1) extracellular space (ARG1) small molecule metabolic process (ARG1)
cellular nitrogen compound metabolic process (ARG1) cytoplasm (ARG1)
Anatomy Link Frequency
macrophage 2
stroma 1
external 1
22Rv1 1
22RV1 1
ARG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 24 99.90 Very High Very High Very High
corticosteroid 12 99.68 Very High Very High Very High
psoriasis 22 99.00 Very High Very High Very High
Inflammation 221 98.80 Very High Very High Very High
cytokine 421 96.64 Very High Very High Very High
agonist 75 95.52 Very High Very High Very High
potassium channel 4 89.28 High High
chemokine 29 88.08 High High
Inflammatory response 3 74.48 Quite High
aspirin 9 68.80 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 3024 99.86 Very High Very High Very High
Cancer 2141 99.28 Very High Very High Very High
Psoriasis 40 99.00 Very High Very High Very High
INFLAMMATION 224 98.80 Very High Very High Very High
Adenoma 112 98.52 Very High Very High Very High
Polyps 87 98.48 Very High Very High Very High
Toxicity 58 98.04 Very High Very High Very High
Hyperplasia 229 97.72 Very High Very High Very High
Malignant Neoplastic Disease 622 96.84 Very High Very High Very High
Familial Adenomatous Polyposis 2 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The implication of an androgen-regulated expression of ARG1 and ARG2 in prostate carcinogenesis requires further investigation.
Gene_expression (expression) of ARG1
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.85 Pain Relevance 0
Furthermore, in order to study whether ARG1 and ARG2 expression by LNCaP cells affected their immunosuppressive potential, PBMCs from healthy donors were activated in the presence of conditioned media from LNCaP+siCTRL or LNCaP+siARG1 or LNCaP+siARG2.
Gene_expression (expression) of ARG1
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.09 Pain Relevance 0
LNCaP cells expressed enzymatically functional ARG1 and ARG2 which, once their protein expression was inhibited, caused a decrease in cellular proliferation and in their immunosuppressive potential.
Gene_expression (expressed) of ARG1 associated with hyperplasia
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
Finally, we observed that IL-8 was upregulated following androgen stimulation and could induce the expression of ARG1 and ARG2.
Gene_expression (expression) of ARG1
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.71 Pain Relevance 0.03
However, to our knowledge, we are the first group to study the expression of ARG1 by PCa cells and define mechanistic consequences leading to its androgen-regulated induction.
Gene_expression (expression) of ARG1 associated with reprotox - general 1
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.28 Pain Relevance 0
It is important to note that expression of ARG1 and ARG2 following IL-8 stimulation was not as substantial as with R1881 stimulation suggesting that other androgen-regulated pathways could be involved.
Gene_expression (expression) of ARG1
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.58 Pain Relevance 0.04
Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 were overexpressed.
Gene_expression (overexpressed) of ARG1
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
Gene expression analyses by qPCR demonstrated that ARG1 mRNA was more abundant in the 22Rv1 cell line (Figure 1A), while ARG1 protein was slightly more expressed by the two HR PCa cell lines (Du145 and PC3) than in the LNCaP cells (Figure 1B, bottom panel).
Gene_expression (expressed) of ARG1 in 22Rv1 associated with reprotox - general 1
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.98 Pain Relevance 0
Altogether, our results provide the first mechanistic evidence of an androgen-driven immunosuppressive pathway in PCa through the expression of ARG1, ARG2 and IL-8 by PCa cells.
Gene_expression (expression) of ARG1 associated with reprotox - general 1
9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.37 Pain Relevance 0
We noted a decreased expression of ARG1 with the highest concentration (40 ┬ÁM) of bicalutamide following R1881 stimulation.
Gene_expression (expression) of ARG1
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.04
In this report, we demonstrate that both ARG1 and ARG2 are expressed by hormone-sensitive (HS) and hormone-refractory (HR) PCa cell lines, with the LNCaP cells having the highest arginase activity.
Gene_expression (expressed) of ARG1 associated with reprotox - general 1
11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.95 Pain Relevance 0
ARG1 and ARG2 expression in PCa
Gene_expression (expression) of ARG1 associated with reprotox - general 1
12) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
Compared to a siCTRL, both siRNA significantly inhibited ARG1 or ARG2 expression (Figure 4A).
Gene_expression (expression) of ARG1
13) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.49 Pain Relevance 0
Collectively, our results reveal that, although both induced by R1881, the signaling pathways leading to ARG1 and ARG2 expression differ for the two enzymes and need to be further examined.
Gene_expression (expression) of ARG1
14) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
In this report, we observed that androgens induced the expression of both ARG1 and ARG2 in HS PCa cell lines.
Gene_expression (expression) of ARG1 associated with reprotox - general 1
15) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.74 Pain Relevance 0
Finally, we stimulated androgen-deprived LNCaP cells with increasing concentration of exogenous IL-8 for 72 hrs and monitored the expression of ARG1 and ARG2.
Gene_expression (expression) of ARG1
16) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.14 Pain Relevance 0.03
We did not evaluate ARG1 protein expression as, in our hands, anti-ARG1 antibodies tested were not suitable for immunohistochemistry on archived formalin-fixed paraffin-embedded tissues.
Gene_expression (expression) of ARG1
17) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.64 Pain Relevance 0
We also observed that androgen deprivation in vitro could decrease ARG2, but not ARG1 protein expression, in LNCaP and 22RV1 cells cultured for seven days in the absence of androgens (Figure 3B).
Gene_expression (expression) of ARG1 in 22RV1
18) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.61 Pain Relevance 0
We demonstrate that PCa cells express both ARG1 and ARG2.
Gene_expression (express) of ARG1 associated with reprotox - general 1
19) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.34 Pain Relevance 0
Contrary to ARG2 gene and protein expression, we clearly demonstrated that the gene and protein expression of ARG1 did not correlate.
Gene_expression (expression) of ARG1
20) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.89 Pain Relevance 0

General Comments

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