INT24473

Context Info Confidence 0.26 First Reported 1988 Last Reported 1988 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0.61

plasma membrane (Brs3) signal transducer activity (Brs3)

Brs3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 3 96.72 antagonist 3 96.16 Calcium channel 6 66.68

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inhibitory effect of BAY on the time-dependent increase in BRS was suppressed by a pretreatment with PN (0.6 micrograms/kg i.c.v.) and by a pretreatment with the muscarinic antagonist atropine methylnitrate (80 micrograms/kg i.c.v.).

Negative_regulation (effect) of Positive_regulation (increase) of BRS associated with antagonist

1) Confidence 0.26 Published 1988 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2461181 Disease Relevance 0 Pain Relevance 0.21

In SHR, i.c.v. injection of BAY (3 microgram/kg) but not PN (0.6 micrograms/kg) suppressed the time dependent increase in BRS.

Negative_regulation (suppressed) of Positive_regulation (increase) of BRS

2) Confidence 0.26 Published 1988 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2461181 Disease Relevance 0 Pain Relevance 0.21

The inhibitory effect of BAY on the time-dependent increase in BRS was suppressed by a pretreatment with PN (0.6 micrograms/kg i.c.v.) and by a pretreatment with the muscarinic antagonist atropine methylnitrate (80 micrograms/kg i.c.v.).

Negative_regulation (suppressed) of Positive_regulation (increase) of BRS associated with antagonist

3) Confidence 0.26 Published 1988 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2461181 Disease Relevance 0 Pain Relevance 0.20

General Comments

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