INT244735

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.48
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ascl1) nucleus (Ascl1)
Anatomy Link Frequency
synapse 2
neurons 1
ventricular zone 1
fibroblasts 1
Ascl1 (Mus musculus)
Pain Link Frequency Relevance Heat
interneuron 72 95.72 Very High Very High Very High
Potency 18 93.64 High High
cerebral cortex 252 90.40 High High
medulla 3 87.68 High High
Pain 2 80.56 Quite High
Serotonin 3 77.32 Quite High
Neurotransmitter 29 76.92 Quite High
GABAergic 360 74.64 Quite High
Raphe 16 57.68 Quite High
antagonist 36 55.08 Quite High
Disease Link Frequency Relevance Heat
Infection 333 99.24 Very High Very High Very High
Neurodegenerative Disease 162 99.24 Very High Very High Very High
Mental Disorders 3 97.24 Very High Very High Very High
Pain 2 80.56 Quite High
Adhesions 1 80.44 Quite High
Stuttering 18 69.64 Quite High
Injury 99 5.00 Very Low Very Low Very Low
Stab Wounds 45 5.00 Very Low Very Low Very Low
Targeted Disruption 35 5.00 Very Low Very Low Very Low
Brain Injury 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a recent study has shown that even mouse embryonic or perinatal fibroblasts, i.e. cells of the mesodermal lineage, can be converted by combined forced expression of three defined factors (Mash1, Brn2, Myt1l) into functional neurons [53].
Gene_expression (expression) of Mash1 in fibroblasts
1) Confidence 0.58 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0
Sonic hedgehog secreted from the floor plate triggers the expression of Mash1 and GATA2 in progenitor cells in the ventricular zone of hindbrain [6], and both genes are essential for the development of 5-HTergic neurons [7], [8]. 5-HTergic neurons are classified into two groups based on their anatomical location: a rostral group located in the pons and a caudal group located in the medulla oblongata.
Gene_expression (expression) of Mash1 in ventricular zone associated with medulla
2) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.18 Pain Relevance 0.23
Consistent with previous data [7], 33.5%±17.8% of astroglia expressing Mash1 alone developed into ?
Gene_expression (expressing) of Mash1
3) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.42 Pain Relevance 0.22
Despite this enhanced degree of differentiation, none of the recorded cells co-expressing Mash1 and Dlx2 showed an autaptic response (Figure S2A, n?
Gene_expression (showed) of Mash1
4) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.35 Pain Relevance 0.13
Moreover, compared to cells expressing Dlx2 alone, Mash1/Dlx2 co-expressing neurons exhibited lower input resistance values (1,237.5±278.8 M?
Gene_expression (expressing) of Mash1 in neurons
5) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.50 Pain Relevance 0.12
In contrast, co-expression of Mash1 and Dlx2 significantly augmented neurogenesis from postnatal astroglia (93.0%±3.1% of ?
Gene_expression (expression) of Mash1 associated with neurodegenerative disease
6) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.51 Pain Relevance 0.17
In agreement with this, we found that co-expression of Mash1 and Dlx2 promoted neurogenesis from astroglia in a synergistic manner to levels similar to Neurog2 (Figure 9).
Gene_expression (expression) of Mash1 associated with neurodegenerative disease
7) Confidence 0.45 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.10 Pain Relevance 0.15
In agreement with this, we found that co-expression of Mash1 and Dlx2 promoted neurogenesis from astroglia in a synergistic manner to levels similar to Neurog2 (Figure 9).
Gene_expression (-) of Mash1 associated with neurodegenerative disease
8) Confidence 0.45 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.10 Pain Relevance 0.15
Along these lines we examined whether co-expression of Mash1 with Dlx2 may further promote the maturation and specification of astroglia into synapse-forming interneurons.
Gene_expression (expression) of Mash1 in synapse
9) Confidence 0.45 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.12 Pain Relevance 0.18
Along these lines we examined whether co-expression of Mash1 with Dlx2 may further promote the maturation and specification of astroglia into synapse-forming interneurons.
Gene_expression (-) of Mash1 in synapse
10) Confidence 0.45 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.12 Pain Relevance 0.18
These include Olig3, Neurog2(Ngn2), Ascl1(Mash1), Gsh1, Gsh2, Math1, Pax3, Pax7, and Ptf1a.
Gene_expression (include) of Ascl1
11) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
In contrast, Mash1 was rarely coexpressed with Lrmp/Jaw1 (3.4–3.5%).
Gene_expression (coexpressed) of Mash1
12) Confidence 0.33 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.08 Pain Relevance 0

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