INT244743

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lhx3) nucleus (Lhx3) intracellular (Lhx3)
protein binding transcription factor activity (Lhx3) DNA binding (Lhx3)
Anatomy Link Frequency
glial cells 1
ventral 1
Lhx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 10 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
dorsal root ganglion 5 5.00 Very Low Very Low Very Low
member 8 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
substantia gelatinosa 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 15 78.44 Quite High
Ganglion Cysts 70 76.44 Quite High
Death 15 57.72 Quite High
Retina Disease 5 45.00 Quite Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the homeodomain-containing transcription factor genes Og9x and Lhx3 are specifically expressed in bipolar cell subsets.
Gene_expression (expressed) of Lhx3
1) Confidence 0.70 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.14 Pain Relevance 0
Data for Car10 and Lhx3 are not shown because the fluorescent in situ hybridization signals for these genes were too weak to detect in dissociated cells.
Gene_expression (shown) of Lhx3
2) Confidence 0.60 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.06 Pain Relevance 0
Additionally, bipolar cells expressing 6330514A18Rik (Fig. 5W,X), Car10 (Fig. 5Y,Z), and Lhx3 (Fig. 5A?
Gene_expression (expressing) of Lhx3
3) Confidence 0.54 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Lhx3 was enriched in its expression eightfold in bipolar cells compared with rod photoreceptor and Müller glial cells in the microarray analysis, but the difference in expression levels was not significant (Table 2), perhaps because Lhx3 is only expressed in a limited subset of bipolar cell types represented in the microarray data set.
Gene_expression (expressed) of Lhx3 in glial cells
4) Confidence 0.54 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.28 Pain Relevance 0
Consistent with this notion, expression of Lhx3 was observed in a small subset of bipolar cells (Fig. 2K).
Gene_expression (expression) of Lhx3
5) Confidence 0.54 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.26 Pain Relevance 0
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Lhx3 in ventral
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

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