INT244762

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (En1) nucleus (En1) DNA binding (En1)
Anatomy Link Frequency
Midbrain 5
embryos 1
ventral 1
En1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 100 100.00 Very High Very High Very High
Dopamine 415 99.20 Very High Very High Very High
Action potential 20 81.28 Quite High
gABA 15 5.00 Very Low Very Low Very Low
Glutamate 15 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
drug abuse 5 5.00 Very Low Very Low Very Low
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 35 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Parkinson's Disease 5 5.00 Very Low Very Low Very Low
Nervous System Malformation 5 5.00 Very Low Very Low Very Low
Mucocutaneous Lymph Node Syndrome 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Drug Dependence 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Midbrain specific paired-like homeodomain transcription factor 3 (Pitx3) and engrailed 1 (En1) were expressed in SPIE-treated cultures, but not detected in untreated cultures.
Gene_expression (expressed) of engrailed 1 in Midbrain associated with midbrain
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.27
RT-PCR and western blot analysis confirmed the expression of midbrain specific markers, including engrailed 1, Nurr1, Pitx3, and dopamine transporter (DAT) in cultures influenced by these four molecules.
Gene_expression (expression) of engrailed 1 in midbrain associated with dopamine and midbrain
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.17
Midbrain specific paired-like homeodomain transcription factor 3 (Pitx3) and engrailed 1 (En1) were expressed in SPIE-treated cultures, but not detected in untreated cultures.
Neg (not) Gene_expression (detected) of engrailed 1 in Midbrain associated with midbrain
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
Comparisons between mutant and heterozygote embryos with Evx1, En1, and Chx10 antibodies were used to confirm this observation (data not shown).
Gene_expression (antibodies) of En1 in embryos
4) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Midbrain specific paired-like homeodomain transcription factor 3 (Pitx3) and engrailed 1 (En1) were expressed in SPIE-treated cultures, but not detected in untreated cultures.
Gene_expression (expressed) of En1 in Midbrain associated with midbrain
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.27
Midbrain specific paired-like homeodomain transcription factor 3 (Pitx3) and engrailed 1 (En1) were expressed in SPIE-treated cultures, but not detected in untreated cultures.
Neg (not) Gene_expression (detected) of En1 in Midbrain associated with midbrain
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of En1 in ventral
7) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

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