INT244763

Context Info Confidence 0.49 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.11

cell differentiation (Lbx1) nucleus (Lbx1) DNA binding (Lbx1)

Anatomy Link Frequency dorsal 2 Lbx1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 2 86.52 Pain 1 66.88 substantia gelatinosa 2 44.08 Dorsal horn neuron 1 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Pain 1 66.88 Targeted Disruption 6 5.00 Apoptosis 2 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The significant increase in the expression levels of these Hox genes in Lbx1 mutants indicates that Lbx1 represses the expression of these Hox genes in at least some dorsal cell populations.

Positive_regulation (increase) of Gene_expression (expression) of Lbx1 in dorsal

1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

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