INT244771

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.27
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Satb2) DNA binding (Satb2) cytoplasm (Satb2)
Anatomy Link Frequency
cleft 1
Satb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 53.28 Quite High
substantia gelatinosa 4 48.96 Quite Low
Pain 4 33.64 Quite Low
imagery 1 11.60 Low Low
medulla 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Dorsal horn neuron 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleft Palate 14 99.40 Very High Very High Very High
Tooth Abnormalities 4 90.56 High High
Convulsion 4 87.32 High High
Congenital Anomalies 30 85.68 High High
Atrophic Skin Disease 1 84.48 Quite High
Heart Defects 3 78.64 Quite High
Craniofacial Abnormalities 2 76.60 Quite High
Ectodermal Dysplasia 1 75.24 Quite High
Syndrome 86 74.40 Quite High
Malformed Nails 1 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although haploinsufficiency of SATB2 has been suggested to cause isolated cleft palate in humans, within our cohort SATB2 deletions show reduced penetrance for cleft palate (Table 1).
Gene_expression (deletions) of SATB2 in cleft associated with cleft palate
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719055 Disease Relevance 0.79 Pain Relevance 0
Table 2 shows that Gbx1, Lmx1b, Satb2 and Lhx1 were expressed at significantly lower levels in mutant green cells.
Gene_expression (expressed) of Satb2
2) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Satb2, Pitx2, Trps1, Tcof1, Cited2), expression changes in the same genes in Nipbl+/?
Gene_expression (expression) of Satb2
3) Confidence 0.54 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.48 Pain Relevance 0
e6, Mafa1, Pknox2, Sall3, Tshz2, Lbxcor1, Gbx2, Satb2, Sal4, and Zic1-5), repressed targets (Isl1, Foxd3, Olig3, Otp, FoxP2, Hmx2, Hmx3, Nr4a2(Nurr1), Sall1), and neutral genes (Sall2, Uncx4.1, Bcl11b) were designed according to the online resource PRIMER BANK.
Gene_expression (designed) of Satb2
4) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0.03

General Comments

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