INT244805

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pax5) nucleus (Pax5) DNA binding (Pax5)
Anatomy Link Frequency
germinal center B cells 1
germline 1
Pax5 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 2 77.44 Quite High
Pain 1 30.48 Quite Low
rheumatoid arthritis 2 26.64 Quite Low
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 82 86.36 High High
Diffuse Large B-cell Lymphoma 112 85.12 High High
Lymphatic System Cancer 244 81.20 Quite High
B-cell Lymphoma 54 80.96 Quite High
Follicular Lymphoma 44 78.04 Quite High
Mantle-cell Lymphoma 66 76.00 Quite High
Chronic Lymphoid Leukemia 8 56.88 Quite High
Pain 1 30.48 Quite Low
Rheumatoid Arthritis 6 26.64 Quite Low
Disease 44 18.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the two paralogs of Pax2, namely Pax8 and Pax5, were expressed at 10.2 and 1.7 fold lower levels in mutant green cells.
Gene_expression (expressed) of Pax5
1) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0.04
IRF8 was coexpressed with PAX-5, Pu.1, and BCL 6 and similar to BCL6, was absent from the small population of IRF4-positive germinal center B cells thought to be committed to postgerminal center developmental programs.
Neg (absent) Gene_expression (coexpressed) of PAX-5 in germinal center B cells
2) Confidence 0.17 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.04 Pain Relevance 0
3), whereas the PAX5, BCL6, BCL1 cyclin D1, and ALK genes were in germline configuration.
Gene_expression (genes) of PAX5 in germline
3) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.36 Pain Relevance 0

General Comments

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