INT244838

Context Info Confidence 0.15 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleus (Lbx1, Foxd3) DNA binding (Lbx1, Foxd3) cell differentiation (Lbx1) transcription factor binding (Foxd3)

Lbx1 (Mus musculus) Foxd3 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 2 5.00 substantia gelatinosa 2 5.00 Dorsal horn neuron 1 5.00 Central nervous system 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 6 5.00 Apoptosis 2 5.00 Pain 1 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Three target genes, Foxd3, Isl1, and Pou4f1, are known to be repressed by Lbx1 [9], [30] and appear in Table 1.

Lbx1 Negative_regulation (repressed) of Foxd3

1) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.