INT244897

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.80
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Uts2r) plasma membrane (Uts2r) signal transducer activity (Uts2r)
Anatomy Link Frequency
Appendix 1
Uts2r (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 81 99.08 Very High Very High Very High
cytokine 36 97.64 Very High Very High Very High
Kinase C 18 97.48 Very High Very High Very High
Inflammation 127 97.24 Very High Very High Very High
Hippocampus 31 93.48 High High
tolerance 7 88.32 High High
Neurotransmitter 20 77.92 Quite High
Inflammatory stimuli 3 73.40 Quite High
Peripheral nervous system 5 52.36 Quite High
metalloproteinase 2 51.36 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 175 98.56 Very High Very High Very High
INFLAMMATION 133 97.24 Very High Very High Very High
Cancer 154 89.52 High High
Disease 178 77.76 Quite High
Adhesions 8 70.56 Quite High
Contagious Ecthyma 2 69.20 Quite High
Myopia 44 50.00 Quite Low
Alcohol Addiction 25 50.00 Quite Low
Cognitive Disorder 31 49.36 Quite Low
Aging 5 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UTR forward primer and the 3?
UTR Binding (primer) of
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.27 Pain Relevance 0.08
UTR (probe set 1418701_at) is strongly cis-modulated in all tissues and is associated with high expression from the D allele.
UTR Binding (associated) of
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.19 Pain Relevance 0
UTR is associated with higher levels of COMT protein expression.


UTR Binding (associated) of associated with catechol-o-methyltransferase
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.40 Pain Relevance 0.17
It binds to the G-protein coupled urotensin II receptor (UTS2R), which was also downregulated in our experiment (Appendix 1, Molecular Transducer Activity, FC=-1.51; Affymetrix ID: GgaAff × 0.1067.1.S1_at).
UTS2R Binding (binds) of in Appendix
4) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0.06
If the effect of URP is indeed the same as of urotensin II, binding to the UTS2R leads to Gq protein activation, associated with activation of protein kinase C, protein tyrosine kinases, calmodulin, and phospholipase C [70-72].
UTS2R Binding (binding) of associated with kinase c
5) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0.05
UTR-ARE leading to its stabilization [96].
UTR-ARE Binding (leading) of
6) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.61 Pain Relevance 0.24
The use of BACE1 constructs devoid in part or all of the 5’UTR demonstrated that the presence of the 5’UTR could depress BACE1 translation significantly.
UTR Binding (presence) of
7) Confidence 0.06 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0
Splicing in the 3' UTR of both human and mouse ADAR2 further contributes to the repertoire of ADAR2 proteins.
UTR Binding (Splicing) of
8) Confidence 0.03 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0
Ethanol exposure increases the expression of a miRNA (miR-9) that binds to 3’UTR sequence specific to the ethanol-sensitive splice variants, and therefore, enhances the degradation of these splice variants.
UTR Binding (binds) of
9) Confidence 0.02 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.19 Pain Relevance 0.23

General Comments

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