INT244959

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.22
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snx1) transport (Snx1) Golgi apparatus (Snx1)
intracellular (Snx1) cytoplasm (Snx1) cytosol (Snx1)
Anatomy Link Frequency
brain 2
extracellular matrix 1
Snx1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 59 97.56 Very High Very High Very High
psoriasis 44 78.20 Quite High
chemokine 17 75.84 Quite High
rheumatoid arthritis 88 61.52 Quite High
Neuropeptide 12 20.08 Low Low
Inflammation 44 7.12 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
member 8 12 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 138 99.52 Very High Very High Very High
Systemic Sclerosis 34 96.88 Very High Very High Very High
Infection 9 94.32 High High
Stress 66 93.92 High High
Disease 81 92.48 High High
Sprains And Strains 9 90.44 High High
Syndrome 126 86.08 High High
Sclerosis 1 84.64 Quite High
Autoimmune Disease 33 83.08 Quite High
Psoriasis 49 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The function of Snx1 in the nervous system has not been well studied, and we speculate that the decreased Snx1 expression we discovered may affect the localization and/or abundance of membrane proteins involved in the development of neonatal brain.
Gene_expression (expression) of Snx1 in brain
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.30 Pain Relevance 0.04
After neonatal starvation, we observed decreased expression only of Snx1, but not of other sorting nexin genes such as Snx2, Snx5 and Snx6.
Gene_expression (expression) of Snx1 associated with starvation
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.31 Pain Relevance 0.05
Five of the chosen six with high to modest level of expression (Ing2, Pgpep1, Brms1l, Ndp, Snx1 and Mett10d) were validated by real-time RT-PCR analysis (all but Ing2) (Fig. 2B and Table 1).


Gene_expression (expression) of Snx1
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.09 Pain Relevance 0
But we detected transcription changes in unexpected genes, Nanos2 and Pdk4, which are increased by roughly 2-fold and 1.5-fold respectively, and Ndp, Pgpep1, Brms1l, Mett10d and Snx1, which are reduced by 25–55% (Figure 2 and Table 1).


Gene_expression (detected) of Snx1
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.25 Pain Relevance 0
Unlike in adult rodents, expression levels of Nanos2 and Pdk4 were increased, and those of Pgpep1, Ndp, Brms1l, Mett10d, and Snx1 were decreased after neonatal deprivation.
Gene_expression (expression) of Snx1
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827556 Disease Relevance 1.00 Pain Relevance 0
Conversely, of the seven genes we found to have validated expression changes after fasting in P5 mice, five have rat orthologs on Affymetrix RG_U34A,B,C chips (Pdk4, Pgpep1, Brms1l, Mett10d and Snx1) and the expression of these genes were unchanged in the adult rat brain after fasting (Table 1).
Gene_expression (expression) of Snx1 in brain
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of SNX3 was specific, since overexpression of other SNX family members, including SNX1, SNX2, and SNX16, did not interfere with EGF receptor transport (Figure S5), as expected [41,42].
Gene_expression (overexpression) of SNX1
7) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2528051 Disease Relevance 0 Pain Relevance 0
SNX1, SNX2, and SNX3 were amplified by PCR and introduced into pEGFP-C2 or fused with mRFP.


Gene_expression (introduced) of SNX1
8) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2528051 Disease Relevance 0.09 Pain Relevance 0
Germany), GFP-tagged SNX1 and Flag-tagged SNX2 from Gordon N.
Gene_expression (tagged) of SNX1
9) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2528051 Disease Relevance 0.07 Pain Relevance 0
Using differential display technology, enhanced expression of extracellular matrix molecules like fibronectin receptor, fibrosin, nexin-1 and insulin-like growth factor binding protein (IGFBP)-5 was demonstrated in SSc.
Gene_expression (expression) of nexin-1 in extracellular matrix associated with systemic sclerosis
10) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.10 Pain Relevance 0.13

General Comments

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