INT245023

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1) intracellular (Xrcc1)
Anatomy Link Frequency
SH-SY5Y 1
Xrcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 20 93.16 High High
Neuroblastoma 20 87.08 High High
Neurodegenerative Disease 15 83.04 Quite High
Hypersensitivity 15 79.04 Quite High
Spinocerebellar Ataxia Type 2 15 77.68 Quite High
Rheumatoid Arthritis 55 77.32 Quite High
Apoptosis 80 69.36 Quite High
Ataxia 25 27.92 Quite Low
Neuropathic Pain 10 21.76 Low Low
Stress 85 11.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable suppression of the XRCC1 protein was achieved using the targeting shRNA system, while the scramble-shRNA infected cells retained XRCC1 expression.
Negative_regulation (suppression) of XRCC1
1) Confidence 0.58 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0
XRCC1 is a key component of SSBR, as cells defective in this nonenzymatic scaffold protein show reduced SSBR, enhanced sensitivity to DNA-damaging agents that produce SSBs, and increased sister chromatid exchange (5).
Negative_regulation (defective) of XRCC1
2) Confidence 0.43 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0 Pain Relevance 0
To determine the functional consequence of XRCC1 down-regulation, we evaluated methyl methanesulfonate (MMS) sensitivity.
Spec (determine) Negative_regulation (regulation) of XRCC1
3) Confidence 0.43 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0
Using hypoxanthine–xanthine oxidase as the oxidizing method, XRCC1 deficiency affected both dividing and nondividing SH-SY5Y cells, with a greater effect on survival seen in the former case, suggesting that the spectrum of oxidative DNA damage created dictates the specific contribution of XRCC1 to cellular resistance.
Negative_regulation (deficiency) of XRCC1 in SH-SY5Y
4) Confidence 0.43 Published 2008 Journal Nucleic Acids Research Section Abstract Doc Link PMC2528184 Disease Relevance 0.32 Pain Relevance 0
Shown is a representative western blot of XRCC1 protein expression in dividing XKD and control cells. ?
Negative_regulation (blot) of XRCC1
5) Confidence 0.42 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.26 Pain Relevance 0

General Comments

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