INT245028

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1) intracellular (Xrcc1)
Anatomy Link Frequency
SH-SY5Y 2
Xrcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 3 46.72 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 12 99.56 Very High Very High Very High
Rheumatoid Arthritis 33 98.64 Very High Very High Very High
Infection 12 88.36 High High
Hypersensitivity 9 73.76 Quite High
Targeted Disruption 3 70.64 Quite High
Stress 51 27.60 Quite Low
Apoptosis 48 5.00 Very Low Very Low Very Low
Ataxia 15 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we note that Narciso et al. (33) recently reported down-regulation of XRCC1 in differentiated human skeletal muscle cells; however, analysis of expressional changes of several DNA damage response genes following RA-BDNF differentiation of SH-SY5Y neuroblastoma cells did not reveal down-regulation of XRCC1 protein expression (Kulkarni and Wilson, unpublished observations), suggesting a cell type-specific regulation of this gene product.
Negative_regulation (down-regulation) of Gene_expression (expression) of XRCC1 in SH-SY5Y associated with neuroblastoma and rheumatoid arthritis
1) Confidence 0.43 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.41 Pain Relevance 0
Resistant colonies were periodically checked for XRCC1 expression using standard western blotting procedures.
Negative_regulation (checked) of Gene_expression (expression) of XRCC1
2) Confidence 0.42 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.05 Pain Relevance 0
Stable suppression of the XRCC1 protein was achieved using the targeting shRNA system, while the scramble-shRNA infected cells retained XRCC1 expression.
Negative_regulation (retained) of Gene_expression (expression) of XRCC1
3) Confidence 0.42 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0

General Comments

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