INT245029

Context Info Confidence 0.45 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.51 Pain Relevance 0

nucleus (Xrcc1) intracellular (Xrcc1)

Anatomy Link Frequency neuronal 1 Xrcc1 (Mus musculus)

Pain Link Frequency Relevance Heat bDMF 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Stress 34 98.82 Apoptosis 32 86.64 Infection 8 79.28 Rheumatoid Arthritis 22 65.28 Hypersensitivity 6 41.16 Ataxia 10 5.00 Neuroblastoma 8 5.00 Spinocerebellar Ataxia Type 2 6 5.00 Neurodegenerative Disease 6 5.00 Neuropathic Pain 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To further investigate the role of XRCC1 in oxidative stress resistance in nondividing neuronal cells, we examined the response of XRCC1-deficient primary cells from both mouse and human in culture.

Spec (examined) Regulation (response) of XRCC1 in neuronal associated with stress

1) Confidence 0.45 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.43 Pain Relevance 0

Methods for down-regulation of XRCC1 were established using an XRCC1 specific TRC shRNA-pLKO.1 plasmid construct and a lentiviral package and delivery system as described in Materials and Methods section.

Regulation (regulation) of XRCC1

2) Confidence 0.45 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.08 Pain Relevance 0

General Comments

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