INT245029

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1) intracellular (Xrcc1)
Anatomy Link Frequency
neuronal 1
Xrcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 34 98.82 Very High Very High Very High
Apoptosis 32 86.64 High High
Infection 8 79.28 Quite High
Rheumatoid Arthritis 22 65.28 Quite High
Hypersensitivity 6 41.16 Quite Low
Ataxia 10 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the role of XRCC1 in oxidative stress resistance in nondividing neuronal cells, we examined the response of XRCC1-deficient primary cells from both mouse and human in culture.
Spec (examined) Regulation (response) of XRCC1 in neuronal associated with stress
1) Confidence 0.45 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.43 Pain Relevance 0
Methods for down-regulation of XRCC1 were established using an XRCC1 specific TRC shRNA-pLKO.1 plasmid construct and a lentiviral package and delivery system as described in Materials and Methods section.
Regulation (regulation) of XRCC1
2) Confidence 0.45 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.08 Pain Relevance 0

General Comments

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