INT245039

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1, Tdp1) intracellular (Xrcc1) cytoplasm (Tdp1)
nuclease activity (Tdp1)
Xrcc1 (Mus musculus)
Tdp1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 28.24 Quite Low
bDMF 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 6 97.96 Very High Very High Very High
Ataxia 10 96.96 Very High Very High Very High
Neuropathic Pain 4 93.88 High High
Neurodegenerative Disease 6 46.24 Quite Low
Cancer 2 34.88 Quite Low
Apoptosis 32 10.40 Low Low
Stress 34 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 22 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent evidence also indicates critical associations of XRCC1 with two proteins, aprataxin and tyrosyl-DNA phosphodiesterase 1 (TDP1), which are defective in the recessive hereditary spinocerebellar ataxias, ataxia with oculomotor apraxia (AOA1) and spinocerebellar ataxia with axonal neuropathy (SCAN1), respectively (10–14).
XRCC1 Binding (associations) of TDP1 associated with ataxia, neuropathic pain and spinocerebellar ataxia type 2
1) Confidence 0.39 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.38 Pain Relevance 0
Recent evidence also indicates critical associations of XRCC1 with two proteins, aprataxin and tyrosyl-DNA phosphodiesterase 1 (TDP1), which are defective in the recessive hereditary spinocerebellar ataxias, ataxia with oculomotor apraxia (AOA1) and spinocerebellar ataxia with axonal neuropathy (SCAN1), respectively (10–14).
XRCC1 Binding (associations) of tyrosyl-DNA phosphodiesterase 1 associated with ataxia, neuropathic pain and spinocerebellar ataxia type 2
2) Confidence 0.39 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.38 Pain Relevance 0

General Comments

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