INT24504

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Context Info
Confidence 0.80
First Reported 1981
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 3.44
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Anpep) peptidase activity (Anpep)
Anatomy Link Frequency
brain 5
cerebral cortex 1
proximal 1
smooth muscle cells 1
BEN 1
Anpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
Pain management 8 100.00 Very High Very High Very High
aspirin 14 99.16 Very High Very High Very High
Paracetamol 16 99.08 Very High Very High Very High
anesthesia 14 98.92 Very High Very High Very High
cerebral cortex 12 94.92 High High
Neuropeptide 6 93.96 High High
Pain 6 93.96 High High
Raphe 1 88.04 High High
Perioperative pain 2 86.04 High High
Disease Link Frequency Relevance Heat
Injury 10 99.80 Very High Very High Very High
Renal Disease 8 97.52 Very High Very High Very High
Balkan Nephropathy 6 97.24 Very High Very High Very High
Pain 10 93.96 High High
Pre-eclampsia 3 87.44 High High
Post Operative Pain 2 86.04 High High
Toxicity 8 78.72 Quite High
Pyelonephritis 1 74.88 Quite High
Proteinuria 2 72.80 Quite High
Polyuria 2 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This iodinated probe could allow the ex vivo and in vivo localization of aminopeptidase N in various tissues to be investigated and may also be used to evaluate quantitative changes in aminopeptidase N expression in pathological situations.
Localization (localization) of aminopeptidase N
1) Confidence 0.80 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672613 Disease Relevance 0.06 Pain Relevance 0.63
In each tissue aminopeptidase M is localized such that it can limit diffusion across specific barriers.
Localization (localized) of aminopeptidase M
2) Confidence 0.80 Published 1987 Journal Peptides Section Abstract Doc Link 2889201 Disease Relevance 0 Pain Relevance 0.31
Immunohistochemical localization of aminopeptidase M in rat brain and periphery: relationship of enzyme localization and enkephalin metabolism.
Localization (localization) of aminopeptidase M in brain associated with enkephalin
3) Confidence 0.80 Published 1987 Journal Peptides Section Title Doc Link 2889201 Disease Relevance 0 Pain Relevance 0.37
Major localization of aminopeptidase M in rat brain microvessels.
Localization (localization) of aminopeptidase M in brain
4) Confidence 0.79 Published 1987 Journal Neuroscience Section Title Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.22
The localization of two enkephalin-hydrolysing aminopeptidases i.e. aminopeptidase M (aminopeptidase N, EC 3.4.11.2) relatively insensitive to puromycin (Ki = 78 microM), and a puromycin-sensitive aminopeptidase (Ki = 1 microM) was studied in rat brain.
Localization (localization) of aminopeptidase N in brain associated with enkephalin
5) Confidence 0.73 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.13
Microvessels represent a major localization of cerebral aminopeptidase M as shown by the intense immunostaining of their walls in sections from various regions as well as in a fraction isolated from cerebral cortex homogenates by a sieving procedure.
Localization (localization) of aminopeptidase M in cerebral cortex associated with cerebral cortex
6) Confidence 0.73 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.19
The localization of two enkephalin-hydrolysing aminopeptidases i.e. aminopeptidase M (aminopeptidase N, EC 3.4.11.2) relatively insensitive to puromycin (Ki = 78 microM), and a puromycin-sensitive aminopeptidase (Ki = 1 microM) was studied in rat brain.
Localization (localization) of aminopeptidase M in brain associated with enkephalin
7) Confidence 0.73 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.13
A rather high aminopeptidase M activity was also localized in choroid plexuses.
Localization (localized) of aminopeptidase M in choroid
8) Confidence 0.73 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.27
These data suggest a dual localization of cerebral aminopeptidase M in microvessels and synaptic membranes consistent with its roles in preventing the access of circulating peptides to brain as well as in inactivating neuropeptides released from cerebral neurones.
Localization (localization) of aminopeptidase M in brain associated with neuropeptide
9) Confidence 0.73 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888044 Disease Relevance 0 Pain Relevance 0.21
Acknowledging the importance of APM, health care accrediting agencies and professional societies have become increasingly focused on ensuring that patients receive prompt and acceptable pain relief.
Localization (importance) of APM associated with pain and pain management
10) Confidence 0.64 Published 2008 Journal Pain Manag Nurs Section Abstract Doc Link 18294589 Disease Relevance 0.50 Pain Relevance 0.61
Acknowledging the importance of APM, health care accrediting agencies and professional societies have become increasingly focused on ensuring that patients receive prompt and acceptable pain relief.
Localization (importance) of APM associated with pain and pain management
11) Confidence 0.64 Published 2008 Journal J. Perianesth. Nurs. Section Abstract Doc Link 18226792 Disease Relevance 0.50 Pain Relevance 0.61
As a marker of renal injury, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) were measured after oral administration of 600 mg/kg of each drug.
Localization (excretion) of alanine aminopeptidase associated with injury
12) Confidence 0.45 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8105522 Disease Relevance 0.51 Pain Relevance 0.34
N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) excretion after acute administration of acetaminophen, salsalate and aspirin in rats.
Localization (excretion) of alanine aminopeptidase associated with aspirin and paracetamol
13) Confidence 0.42 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 8105522 Disease Relevance 0.48 Pain Relevance 0.45
Urinary excretion of alanine aminopeptidase (AAP) is an extremely sensitive indicator of drug-induced renal tubular damage.
Localization (excretion) of alanine aminopeptidase
14) Confidence 0.26 Published 1988 Journal Anesth. Analg. Section Abstract Doc Link 2899408 Disease Relevance 0 Pain Relevance 0.22
The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides.
Localization (excretion) of alanine aminopeptidase associated with anesthesia
15) Confidence 0.25 Published 1988 Journal Anesth. Analg. Section Title Doc Link 2899408 Disease Relevance 0 Pain Relevance 0.26
Postanesthesia BUN and serum creatinine concentrations decreased, creatinine clearance increased, and urinary N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase excretion increased in all groups compared with preanesthesia values, but there were no significant differences between the low-flow sevoflurane, high-flow sevoflurane, and low-flow isoflurane groups for any renal function parameter at any time after anesthesia.
Localization (excretion) of alanine aminopeptidase
16) Confidence 0.24 Published 1997 Journal Anesthesiology Section Body Doc Link 9197291 Disease Relevance 0 Pain Relevance 0
This polycarbophil-cysteine conjugate also had a significantly greater inhibitory activity than unmodified polycarbophil on the activity of isolated aminopeptidase N and aminopeptidase N present on intact intestinal mucosa23.
Localization (present) of aminopeptidase N
17) Confidence 0.10 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0
This polycarbophil-cysteine conjugate also had a significantly greater inhibitory activity than unmodified polycarbophil on the activity of isolated aminopeptidase N and aminopeptidase N present on intact intestinal mucosa23.
Localization (present) of aminopeptidase N
18) Confidence 0.10 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0
Excretion of aminopeptidase N (APN) activity before acetaminophen treatment was significantly higher in patients with GN, however, NAGA excretion was higher in both GN and BEN patients than in healthy controls.
Localization (Excretion) of aminopeptidase N in BEN associated with paracetamol, balkan nephropathy and renal disease
19) Confidence 0.06 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.07 Pain Relevance 0.86
Urinary excretion of the low molecular weight protein beta 2-microglobulin and tubular enzymes--alanine aminopeptidase (AAP), gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (AP)--are very sensitive parameters for proximal tubular lesions.
Localization (excretion) of alanine aminopeptidase in proximal
20) Confidence 0.02 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.32 Pain Relevance 0

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