INT245073

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, CXCR4) signal transducer activity (CXCR4) extracellular space (VEGFA)
extracellular region (VEGFA) growth (VEGFA) proteinaceous extracellular matrix (VEGFA)
VEGFA (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 40 48.32 Quite Low
adenocard 32 30.36 Quite Low
chemokine 92 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 476 100.00 Very High Very High Very High
Glioma 12 97.40 Very High Very High Very High
Colon Cancer 84 75.88 Quite High
Metastasis 172 75.04 Quite High
Ovarian Cancer 16 72.96 Quite High
Breast Cancer 100 71.20 Quite High
Reprotox - General 1 28 69.52 Quite High
Osteogenic Sarcomas 8 66.36 Quite High
Hypoxia 44 49.00 Quite Low
Carcinoma 28 39.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF is present in high levels in tumors and may upregulate CXCR4
VEGF Spec (may) Positive_regulation (upregulate) of CXCR4 associated with cancer
1) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.32 Pain Relevance 0
VEGF can also upregulate CXCR4
VEGF Positive_regulation (upregulate) of CXCR4
2) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.26 Pain Relevance 0
Firstly, VEGF can promote CXCR4
VEGF Positive_regulation (promote) of CXCR4
3) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.19 Pain Relevance 0
In the case of tumor cells, this upregulation of CXCR4 by VEGF
VEGF Positive_regulation (upregulation) of CXCR4 associated with cancer
4) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.32 Pain Relevance 0

General Comments

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