INT245085

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.70
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 95.44 Very High Very High Very High
antagonist 20 61.76 Quite High
agonist 10 58.08 Quite High
adenocard 16 35.40 Quite Low
chemokine 46 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 20 95.44 Very High Very High Very High
Cancer 238 90.84 High High
Glioma 6 82.16 Quite High
Colon Cancer 42 80.92 Quite High
Metastasis 86 80.08 Quite High
Osteogenic Sarcomas 4 71.40 Quite High
Hypoxia 22 54.04 Quite High
Carcinoma 14 44.44 Quite Low
Familial Adenomatous Polyposis 2 41.36 Quite Low
Ovarian Cancer 8 40.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The

existence of a mechanism of 15dPGJ2-induced CXCR4 downregulation

Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4
1) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.45 Pain Relevance 0.23
signalling leads to downregulation of both VEGF receptor 2 and CXCR4 [142].
Positive_regulation (leads) of Negative_regulation (downregulation) of CXCR4
2) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.25 Pain Relevance 0

General Comments

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