INT245089

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 10.17
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
blood 1
stromal cells 1
bone marrow 1
platelet 1
articular cartilage 1
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 50 99.74 Very High Very High Very High
Inflammation 101 94.92 High High
adenocard 16 90.40 High High
chemokine 462 87.68 High High
antagonist 56 86.40 High High
cytokine 88 85.36 High High
fibrosis 1 72.28 Quite High
agonist 14 63.32 Quite High
Inflammatory response 6 8.24 Low Low
metalloproteinase 104 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 52 99.74 Very High Very High Very High
Infection 114 99.68 Very High Very High Very High
Breast Cancer 90 99.68 Very High Very High Very High
Herpes Simplex Virus 238 99.48 Very High Very High Very High
Ovarian Cancer 348 99.40 Very High Very High Very High
Cancer 882 99.08 Very High Very High Very High
Leukemia 41 98.52 Very High Very High Very High
Malignant Neoplastic Disease 58 97.38 Very High Very High Very High
Pressure And Volume Under Development 40 97.08 Very High Very High Very High
Hypoxia 27 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cells, leading to increased migration towards CXCL12 due to the activation of
Localization (leading) of CXCL12
1) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.55 Pain Relevance 0.18
CXCR4, and are attracted to CXCL12 produced by stromal cells in specialized bone
Localization (attracted) of CXCL12 in stromal cells
2) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.33 Pain Relevance 0.07
Stromal cells within bone marrow microenvironment constitutively secrete CXCL12 and the activation of CXCR4 induces leukemia cell migration to the marrow microenvironment, providing growth and drug resistance signals.
Localization (secrete) of CXCL12 in bone marrow associated with leukemia
3) Confidence 0.61 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.47 Pain Relevance 0.03
Moreover, coculture experiments, using HPMCs and EOC, showed a strong increase in CXCL12 release, suggesting that some tumor-derived factors upregulate CXCL12 levels in ascites.
Localization (release) of CXCL12 associated with pressure and volume under development, cancer and ovarian cancer
4) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.47 Pain Relevance 0.04
Malignant breast cancer cells express CXCR4, invade the extracellular matrix, and circulate in the blood and lymphatic vessels attracted by CXCL12 that is abundantly released by target metastatic organs.
Localization (released) of CXCL12 in blood associated with malignant neoplastic disease and breast cancer
5) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.56 Pain Relevance 0.03
OA osteoblasts release more IL-6, CXCL12, CXCL13 and leptin that can also directly modulate COLLI synthesis, promote articular cartilage degradation and contribute to inflammatory state observed in OA.
Localization (release) of CXCL12 in articular cartilage associated with inflammation and osteoarthritis
6) Confidence 0.24 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.91 Pain Relevance 0.29
Malignant breast cancer cells express CXCR4, invade the extracellular matrix, and circulate in the blood and lymphatic vessels attracted by CXCL12 that is abundantly released by target metastatic organs.
Localization (released) of CXCL12 in lymphatic vessels associated with malignant neoplastic disease and breast cancer
7) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.56 Pain Relevance 0.03
KSHV infection stimulated the secretion of growth factors and angiogenic factors such as insulin-like growth factor-1 (IGF-1), platelet derived growth factor-BB (PDGF-BB), macrophage colony stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), GM-CSF, angiogenin (Ang), oncostatin-M (Onco-M), TPO (thrombopoietin), VEGF, stromal cell-derived factor-1 (SDF-1), SCF (stem cell factor), TGF-?
Localization (secretion) of SDF-1 in platelet associated with herpes simplex virus and infection
8) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.31 Pain Relevance 0.61

General Comments

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