INT2451

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Context Info
Confidence 0.70
First Reported 1979
Last Reported 2010
Negated 26
Speculated 13
Reported most in Abstract
Documents 355
Total Number 369
Disease Relevance 102.66
Pain Relevance 147.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 87
PVN 35
hypothalamus 12
blood 11
neurons 11
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 219 100.00 Very High Very High Very High
Enkephalin 192 100.00 Very High Very High Very High
anesthesia 184 100.00 Very High Very High Very High
Dopamine 117 100.00 Very High Very High Very High
withdrawal 95 100.00 Very High Very High Very High
noradrenaline 53 100.00 Very High Very High Very High
cocaine 51 100.00 Very High Very High Very High
visual analogue scale 40 100.00 Very High Very High Very High
Catecholamine 39 100.00 Very High Very High Very High
Spinal cord 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 99 100.00 Very High Very High Very High
Cv General 3 Under Development 43 100.00 Very High Very High Very High
Hemorrhage 104 99.98 Very High Very High Very High
Dysmenorrhea 21 99.98 Very High Very High Very High
Hypoglycemia 10 99.98 Very High Very High Very High
Decapitation 4 99.98 Very High Very High Very High
Stress 498 99.92 Very High Very High Very High
Pressure Volume 2 Under Development 124 99.90 Very High Very High Very High
Anxiety Disorder 40 99.84 Very High Very High Very High
Hypoxia 40 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of bacterial lipopolysaccharide (LPS)-induced fever by intraperitoneal indomethacin resulted in significant increases in AVP levels in VSA perfusion fluid (P < 0.05).
Positive_regulation (increases) of AVP in VSA associated with fever
1) Confidence 0.70 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8322966 Disease Relevance 0.15 Pain Relevance 0.26
Circulating vasopressin levels were increased after NA injection into the CC.
Positive_regulation (increased) of vasopressin associated with noradrenaline
2) Confidence 0.70 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12681374 Disease Relevance 0.17 Pain Relevance 0.58
While AVP heteronuclear (hn) RNA was not detected in the PVN under basal conditions, a marked induction of AVP hnRNA was observed after 2 and 3 h incubation of slices with forskolin.
Positive_regulation (induction) of AVP hnRNA in PVN
3) Confidence 0.70 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.11
In contrast to the stimulatory effects of forskolin, phorbol 12-myristate 13-acetate (PMA) was completely ineffective in inducing AVP hnRNA in the PVN at any time examined (1-3 h).
Spec (examined) Positive_regulation (inducing) of AVP hnRNA in PVN
4) Confidence 0.70 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.13
AVP heteronuclear (hn) RNA, an indicator for gene transcription, was induced in the PVN with incubation of forskolin as reported previously, and AVP mRNA was increased by forskolin in the presence of the gene transcription inhibitor 5,6-dichloro-1-D-ribofuranosylbenzimidazole (DRB).
Positive_regulation (increased) of AVP mRNA in PVN
5) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.29
Thus, it was demonstrated that: (1) cAMP upregulates AVP gene transcriptionally and post-transcriptionally, (2) the mode of action of glucocorticoids was dependent on whether the cells were stimulated by cAMP, and (3) the interactions between cAMP and glucocorticoids encompass both gene transcription and mRNA stability.
Positive_regulation (upregulates) of AVP gene
6) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.59
Prior treatment with U50 488H or morphine attenuated the increase in plasma concentrations of AVP stimulated by i.c.v. injection of hypertonic NaCl from 13.92 +/- 4.44 to 1.22 +/- 0.34 and 1.78 +/- 0.74 pmol/l respectively (n = 7; P less than 0.05).
Positive_regulation (increase) of AVP in plasma associated with morphine
7) Confidence 0.70 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1648591 Disease Relevance 0 Pain Relevance 0.64
In contrast, animals showing little to no defensive burying responses displayed relatively higher levels of AVP and oxytocin (OT) mRNA within the supraoptic nucleus and subregions of the paraventricular nucleus of the hypothalamus responsible for neuroendocrine and autonomic function.
Positive_regulation (levels) of AVP in autonomic
8) Confidence 0.70 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19540895 Disease Relevance 0.15 Pain Relevance 0.19
The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid.
Positive_regulation (increase) of AVP in neurons associated with raphe magnus, pain and glutamate
9) Confidence 0.70 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.61 Pain Relevance 1.09
Our previous study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation.
Positive_regulation (increase) of AVP in nucleus associated with raphe magnus and pain
10) Confidence 0.70 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.60 Pain Relevance 0.91
The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid.
Positive_regulation (increased) of AVP in neurons associated with raphe magnus, pain and glutamate
11) Confidence 0.70 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.63 Pain Relevance 1.09
After bilateral cervical vagotomy, 60 degrees head-up tilt for 30 min increased AVP, but the change was significantly reduced compared to intact animals.
Positive_regulation (increased) of AVP in head
12) Confidence 0.70 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1922676 Disease Relevance 0.08 Pain Relevance 0.03
However, the increased circulating AVP is not necessary for the maintenance of arterial pressure.
Positive_regulation (increased) of AVP
13) Confidence 0.70 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1922676 Disease Relevance 0 Pain Relevance 0.04
Centrally released arginine vasopressin (AVP) has been implicated in the regulation of the brain water content and is elevated in the cerebrospinal fluid of patients with ischaemic and traumatic brain injuries.
Positive_regulation (elevated) of AVP in brain associated with brain injury
14) Confidence 0.70 Published 1997 Journal Acta Neurochir (Wien) Section Abstract Doc Link 9479425 Disease Relevance 0.33 Pain Relevance 0.09
Hypotensive hemorrhage elevates corticotropin-releasing hormone messenger ribonucleic acid (mRNA) but not vasopressin mRNA in the rat hypothalamus.
Neg (not) Positive_regulation (elevates) of vasopressin mRNA in hypothalamus associated with cva
15) Confidence 0.70 Published 1992 Journal Endocrinology Section Title Doc Link 1311234 Disease Relevance 0.82 Pain Relevance 0.54
During epidural anaesthesia, plasma arginine vasopressin (AVP) concentrations are increased.
Positive_regulation (increased) of AVP in plasma associated with epidural
16) Confidence 0.70 Published 2008 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 18683483 Disease Relevance 0.44 Pain Relevance 0.25
During epidural anaesthesia, plasma arginine vasopressin (AVP) concentrations are increased.
Positive_regulation (increased) of arginine vasopressin in plasma associated with epidural
17) Confidence 0.70 Published 2008 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 18683483 Disease Relevance 0.44 Pain Relevance 0.25
These results show an involvement of the SFO in the mechanism of osmotic activation of putative vasopressin (AVP)-secreting neurons in the PVN.
Positive_regulation (activation) of vasopressin in PVN
18) Confidence 0.69 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2710398 Disease Relevance 0 Pain Relevance 0.34
Blocking the action of opioid peptides with naloxone during osmotic stimulation augmented the rise in plasma OT in rats of all ages but further elevated plasma AVP only in immature rats.
Positive_regulation (elevated) of AVP in plasma associated with narcan and opioid
19) Confidence 0.69 Published 1986 Journal Endocrinology Section Abstract Doc Link 3720659 Disease Relevance 0 Pain Relevance 0.54
On the other hand, decapitation increased the plasma vasopressin concentration to 6.0 +/- 2.4 (in pg/ml) (n = 6), inactin anesthesia to 2.9 +/- 0.6 (n = 6), anesthesia and femoral cannulation to 13.3 +/- 5.8 (n = 6) and surgery for renal micropuncture to 81.3 +/- 35.0 (n = 6).
Positive_regulation (increased) of vasopressin in plasma associated with anesthesia and decapitation
20) Confidence 0.69 Published 1992 Journal Experientia Section Abstract Doc Link 1547858 Disease Relevance 0.10 Pain Relevance 0.36

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