INT245105

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Axin1) enzyme binding (Axin1) protein complex (Axin1)
cytoplasm (Axin1) signal transducer activity (Axin1) signal transduction (Axin1)
Axin1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 50.00 Quite Low
sodium channel 19 29.24 Quite Low
palliative 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
dysesthesia 2 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Hyperesthesia 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 1 96.64 Very High Very High Very High
Disease 3 93.96 High High
Cancer 19 91.32 High High
Metastasis 23 59.56 Quite High
Prostate Cancer 35 58.92 Quite High
Osteolysis 4 55.20 Quite High
Poisoning 217 50.00 Quite Low
Ciguatera Poisoning 54 50.00 Quite Low
Toxicity 32 34.72 Quite Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then, each competitive experiment yields a sigmoidal dose-response curve with binding parameter data such as the concentration of cold competitor that induces 50% inhibitory radiolabeled binding (IC50), Kd (dissociation constant), Ki (inhibition constant), Hill slope, and Bmax (total binding sites).
Ki Binding (binding) of
1) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0
These selective inhibitors are hoped to have a ratio of at least 1000 between the Ki (the dissociation constant for binding of inhibitor) values for mmp anti-targets and those for mmp targets 38,39.
Ki Binding (binding) of
2) Confidence 0.05 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.65 Pain Relevance 0

General Comments

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