INT245115

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.23
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ELF3) nucleolus (ELF3) nucleus (ELF3)
extracellular matrix organization (ELF3) embryo development (ELF3) cytoplasm (ELF3)
ELF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 20 66.40 Quite High
tolerance 10 22.40 Low Low
Pain 36 5.00 Very Low Very Low Very Low
Action potential 36 5.00 Very Low Very Low Very Low
Spinal cord 25 5.00 Very Low Very Low Very Low
imagery 23 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
cva 13 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
repetitive firing 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 191 99.98 Very High Very High Very High
Fabry Disease 276 99.80 Very High Very High Very High
Urticaria 2 99.16 Very High Very High Very High
Apnoea 2 91.88 High High
Renal Disease 113 90.60 High High
Disease 150 90.40 High High
Chronic Renal Failure 56 89.32 High High
Lysosome Storage Disease 13 85.16 High High
Body Weight 5 80.72 Quite High
Fever 8 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four patients from the Fabry Outcomes Survey Registry have been described with similar degrees of proteinuria during ERT (222.8 ± 60 [SEM] mg/day) who progressed at ?
Positive_regulation (during) of Gene_expression (progressed) of ERT associated with proteinuria
1) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.79 Pain Relevance 0
C) Are short-term changes in urinary GL-3 excretion of any utility is assessing response to ERT therapy?
Positive_regulation (response) of Gene_expression (therapy) of ERT
2) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.21 Pain Relevance 0.03
Approximately half the patients had urticaria during IDUA infusion, but in general the ERT was tolerated well.
Positive_regulation (tolerated) of Gene_expression (tolerated) of ERT associated with urticaria
3) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727896 Disease Relevance 0.36 Pain Relevance 0.03
Practical considerations of ERT for Fabry disease
Positive_regulation (considerations) of Gene_expression (considerations) of ERT associated with fabry disease
4) Confidence 0.20 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.88 Pain Relevance 0
Since eRT is dependent on both ?
Positive_regulation (Since) of Gene_expression (dependent) of eRT
5) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0
The eRT was assumed to be approximately equal to the sum of ?
Positive_regulation (approximately) of Gene_expression (equal) of eRT
6) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0
7.7±0.8 ms and the average eRT was ??
Positive_regulation (average) of Gene_expression (average) of eRT
7) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0
Due to its natural relevance to lysosomal delivery, traditionally only M6P was used for ERT via M6P/IGF2R.
Positive_regulation (relevance) of Gene_expression (used) of ERT
8) Confidence 0.09 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0

General Comments

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