INT245156

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
monocytes 2
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 36 93.08 High High
Arthritis 42 87.36 High High
chemokine 7 54.36 Quite High
Inflammation 25 53.92 Quite High
cytokine 17 53.92 Quite High
Peripheral nerve injury 4 50.00 Quite Low
tolerance 1 36.64 Quite Low
rheumatoid arthritis 11 19.84 Low Low
Etanercept 6 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 4 89.28 High High
Seronegative Spondarthritis 40 87.36 High High
Muscular Dystrophy 40 83.32 Quite High
Aging 2 73.08 Quite High
Disease 25 62.40 Quite High
Increased Venous Pressure Under Development 2 56.36 Quite High
INFLAMMATION 24 53.92 Quite High
Graft Vs Host Disease 1 50.32 Quite High
Nervous System Injury 16 50.00 Quite Low
Necrosis 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The identity of gated cells was further confirmed to be microglial, as opposed to intravascular neutrophils or monocytes, by their lower levels of CD45 expression (Sedgwick et al., 1991) in control and injured rats (data not shown).
Negative_regulation (levels) of Gene_expression (expression) of CD45 in monocytes
1) Confidence 0.41 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.06 Pain Relevance 0.05
blockers induced a significant down-regulation in CD45 (1157.0 ± 712.9 and 545.8 ± 253.2, P = 0.007) and CD3 (402.8 ± 203.0 and 224.8 ± 107.7, P = 0.039) ST expression.


Negative_regulation (down) of Gene_expression (expression) of CD45
2) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.28 Pain Relevance 0.16
Furthermore, flow cytometric analyses of T-MPCs confirmed the non-hematopoietic and non-endothelial nature of T-MPCs, based on their lack of expression of CD45 and CD31, respectively.
Negative_regulation (lack) of Gene_expression (expression) of CD45
3) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.15 Pain Relevance 0
Nevertheless, they lack the expression of CD45, CD34, CD14, CD43, and of HLA-DR.
Negative_regulation (lack) of Gene_expression (expression) of CD45
4) Confidence 0.05 Published 2008 Journal J Transl Med Section Body Doc Link PMC2529267 Disease Relevance 0.41 Pain Relevance 0

General Comments

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