INT245157

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.79
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
muscles 4
spinal 2
hip 2
hearts 2
parathyroid 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 73 71.00 Quite High
Inflammation 18 51.76 Quite High
corticosteroid 7 45.20 Quite Low
headache 2 23.52 Low Low
Paresthesia 2 6.04 Low Low
cva 14 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Postmenopausal Osteoporosis 37 98.52 Very High Very High Very High
Spinal Fractures 1 98.36 Very High Very High Very High
Muscular Dystrophy 370 97.76 Very High Very High Very High
Osteoporosis 199 95.20 Very High Very High Very High
Cardiomyopathy 126 92.80 High High
Leukemia 7 92.64 High High
Central Core Disease 3 90.20 High High
Nemaline Myopathy 3 88.92 High High
Mitochondrial Myopathies 4 85.72 High High
Mixed Connective Tissue Disorder 1 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Auxiliary techniques such as immunohistochemistry were frequently requested (74%) in order to achieve a more distinct diagnosis, as illustrated by lack of dystrophin expression (Figure 1).
Negative_regulation (lack) of Gene_expression (expression) of dystrophin
1) Confidence 0.57 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852747 Disease Relevance 1.30 Pain Relevance 0.03
However, the results were not encouraging as the dystrophin expression was limited to the transplanted cells.
Negative_regulation (limited) of Gene_expression (expression) of dystrophin
2) Confidence 0.57 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.86 Pain Relevance 0.04
It is also able to restore the dystrophin expression in the hearts of mdx mice after 4 weeks of treatment [87].
Negative_regulation (restore) of Gene_expression (expression) of dystrophin in hearts
3) Confidence 0.41 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.54 Pain Relevance 0
The percentage of patients who had measured BMD gains ?
Negative_regulation (measured) of Gene_expression (gains) of BMD
4) Confidence 0.16 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.39 Pain Relevance 0
They also reported decreased BMD levels, resulting from high parathyroid hormone levels - the direct outcome of vitamin D deficiency.
Negative_regulation (decreased) of Gene_expression (levels) of BMD in parathyroid
5) Confidence 0.07 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2768686 Disease Relevance 0.71 Pain Relevance 0
These results suggest that parathyroid hormone treatment in conjunction with estrogen therapy results in a significant BMD increase in the lumbar spine and hip in postmenopausal women with GIOP when compared with treatment with estrogen alone.34 However, what is more interesting is that bone mass continued to increase after parathyroid hormone treatment (of 12 months’ duration) was discontinued, and this is particularly true for BMD values at the total hip and femoral neck.34
Negative_regulation (neck.34) of Gene_expression (values) of BMD in hip associated with osteoporosis
6) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.19 Pain Relevance 0
The antifracture efficacy of teriparatide on spinal fracture does not seem to be modulated by age of the subjects (<65, 65–75, or >75 years), prevalent spinal BMD values (T-score <?
Negative_regulation (prevalent) of Gene_expression (values) of BMD in spinal associated with spinal fractures
7) Confidence 0.04 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.31 Pain Relevance 0
Although all dogs showed engraftment of hIDPSC in muscles, only one of them (MT1-S) showed human dystrophin expression.
Negative_regulation (showed) of Gene_expression (expression) of dystrophin in muscles
8) Confidence 0.03 Published 2008 Journal J Transl Med Section Body Doc Link PMC2529267 Disease Relevance 0.49 Pain Relevance 0.03
Human dystrophin expression in muscles of GRDM dogs
Negative_regulation (Human) of Gene_expression (expression) of dystrophin in muscles
9) Confidence 0.03 Published 2008 Journal J Transl Med Section Body Doc Link PMC2529267 Disease Relevance 0 Pain Relevance 0

General Comments

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