INT245172

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 12.97
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)
Anatomy Link Frequency
lung 10
HPAC 6
skin 4
colon 3
CFPAC-1 3
MDK (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 64 100.00 Very High Very High Very High
dexamethasone 384 99.44 Very High Very High Very High
bDMF 36 96.68 Very High Very High Very High
Inflammation 16 92.08 High High
Nerve growth factor 18 32.80 Quite Low
palliative 11 26.68 Quite Low
ketamine 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
fifth nerve 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 368 99.98 Very High Very High Very High
Pancreatic Cancer 561 99.84 Very High Very High Very High
Malignant Neoplastic Disease 55 99.36 Very High Very High Very High
Cancer 404 99.28 Very High Very High Very High
Gastrointestinal Neoplasms 11 98.56 Very High Very High Very High
Apoptosis 11 96.96 Very High Very High Very High
INFLAMMATION 8 92.08 High High
Neurodegenerative Disease 11 90.84 High High
Targeted Disruption 24 87.76 High High
Hypoxia 8 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to present data, among the factors identified in the antler, only Midkine is significantly overexpressed in the antler velvet with respect to normal skin, suggesting a possible role promoting fast axonal growth.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Midkine in skin
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
The only exception is Midkine, which was significantly overexpressed in the velvet respect to frontal skin samples, though not respect to pedicle skin.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Midkine in skin
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.07 Pain Relevance 0
Only Midkine expression appeared significantly upregulated in velvet compared to frontal samples, although it remained unchanged compared to pedicle.
Spec (appeared) Positive_regulation (upregulated) of Gene_expression (expression) of Midkine
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.11
Midkine expression was increased in pancreatic cancer cell lines and pancreatic cancer tissues.
Positive_regulation (increased) of Gene_expression (expression) of Midkine associated with pancreatic cancer
4) Confidence 0.36 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.71 Pain Relevance 0
In contrast, Ad5MK had no effect on AsPC-1 cells as far as the designated conditions, although these cells showed strong midkine expression.
Positive_regulation (strong) of Gene_expression (expression) of midkine in AsPC-1
5) Confidence 0.36 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.40 Pain Relevance 0
MK expression increased 10-fold during cell culture without hormones or serum.
Positive_regulation (increased) of Gene_expression (expression) of MK
6) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.40 Pain Relevance 0.21
Midkine mRNA expression was strong in AsPC-1 and CFPAC-1 cells, but it was weak in MIAPaCa-2 cells.
Positive_regulation (strong) of Gene_expression (expression) of Midkine mRNA in CFPAC-1
7) Confidence 0.27 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.25 Pain Relevance 0
While these observations provided a potential mechanism for the integration of GC and retinoid effects in late gestation fetal lung development, whether GC and RA also influence MK gene expression during postnatal lung development remained unknown.
Spec (whether) Positive_regulation (influence) of Gene_expression (expression) of MK gene in lung associated with rheumatoid arthritis
8) Confidence 0.25 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.50 Pain Relevance 0
Midkine expression is increased in various human tumors, including gastrointestinal cancers [19-22].
Positive_regulation (increased) of Gene_expression (expression) of Midkine associated with cancer and gastrointestinal neoplasms
9) Confidence 0.24 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.82 Pain Relevance 0
Both midkine mRNA expression and midkine protein expression were strong in AsPC-1 and CFPAC-1 cell liens, moderate in BxPC-3, HPAC, and Suit-2 cell lines, and weak in PANC-1 and MIAPaCa-2 cell lines.
Positive_regulation (strong) of Gene_expression (expression) of midkine protein in HPAC
10) Confidence 0.24 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 1.06 Pain Relevance 0
Midkine expression is increased in a number of malignant tumors, including esophageal, stomach, colon, hepatocellular, breast and pancreatic carcinoma, when compared with the level of expression in adjacent non-cancerous tissues [19-22].
Positive_regulation (increased) of Gene_expression (expression) of Midkine in colon associated with malignant neoplastic disease and pancreatic cancer
11) Confidence 0.24 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 1.07 Pain Relevance 0
Both midkine mRNA expression and midkine protein expression were strong in AsPC-1 and CFPAC-1 cell liens, moderate in BxPC-3, HPAC, and Suit-2 cell lines, and weak in PANC-1 and MIAPaCa-2 cell lines.
Positive_regulation (strong) of Gene_expression (expression) of midkine mRNA in HPAC
12) Confidence 0.24 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 1.08 Pain Relevance 0
High levels of MK expression are observed at embryonic day (E)13-16.5 and then again at postnatal days 5-12, primarily in respiratory epithelium early in lung development and increasingly localized to lung stroma and pulmonary blood vessels postnatally [21].
Positive_regulation (levels) of Gene_expression (expression) of MK in epithelium
13) Confidence 0.23 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.15 Pain Relevance 0
We hypothesized that MK expression in both lungs and in isolated AT2 cells would be decreased by corticosteroids and increased by RA.


Positive_regulation (increased) of Gene_expression (expression) of MK in lungs associated with corticosteroid and rheumatoid arthritis
14) Confidence 0.23 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.64 Pain Relevance 0.12
DEX treatment of rat pups decreased, and RA treatment increased lung MK expression, whereas concurrent DEX+RA treatment prevented the DEX-induced decrease in MK expression.
Positive_regulation (increased) of Gene_expression (expression) of MK in lung associated with rheumatoid arthritis and dexamethasone
15) Confidence 0.20 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.68 Pain Relevance 0.48
Further, in the normal developing lung, MK expression increases from PN2, peaks at PN4, and decreases thereafter [8].
Positive_regulation (increases) of Gene_expression (expression) of MK in lung
16) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.66 Pain Relevance 0.26
This finding is in concordance with Matsuura et al. who showed a transient increase in MK expression in normal lungs between two to seven days postnatally [8].
Positive_regulation (increase) of Gene_expression (expression) of MK in lungs
17) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.38 Pain Relevance 0.04
Using human alveolar type 2 (AT2)-like cells differentiated in culture, we confirmed that DEX and cAMP decreased, and RA increased MK expression.


Positive_regulation (increased) of Gene_expression (expression) of MK associated with rheumatoid arthritis and dexamethasone
18) Confidence 0.20 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.64 Pain Relevance 0.44
Midkine mRNA expression was strong in AsPC-1 and CFPAC-1 cells, but it was weak in MIAPaCa-2 cells.
Positive_regulation (strong) of in AsPC-1 Gene_expression (expression) of Midkine mRNA in CFPAC-1
19) Confidence 0.09 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.25 Pain Relevance 0
Both midkine mRNA expression and midkine protein expression were strong in AsPC-1 and CFPAC-1 cell liens, moderate in BxPC-3, HPAC, and Suit-2 cell lines, and weak in PANC-1 and MIAPaCa-2 cell lines.
Positive_regulation (strong) of in BxPC-3 Gene_expression (expression) of midkine protein in HPAC
20) Confidence 0.08 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 1.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox