INT245174

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 5.05
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)
Anatomy Link Frequency
lungs 2
MDK (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 336 99.54 Very High Very High Very High
Inflammation 16 77.56 Quite High
corticosteroid 59 74.96 Quite High
Pain 1 56.32 Quite High
palliative 2 48.64 Quite Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 322 99.80 Very High Very High Very High
Suicidal Behaviour 6 99.60 Very High Very High Very High
Embryonal Carcinoma 2 99.16 Very High Very High Very High
Targeted Disruption 21 98.88 Very High Very High Very High
Pancreatic Cancer 102 98.36 Very High Very High Very High
Cancer 79 91.76 High High
Gastrointestinal Neoplasms 2 88.12 High High
Infection 66 83.28 Quite High
Malignant Neoplastic Disease 10 83.04 Quite High
Neurodegenerative Disease 2 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corresponding to the architecture in RA-alone treated lungs, an increase in MK similar to control animals was seen at PN5.
Positive_regulation (increase) of MK in lungs associated with rheumatoid arthritis
1) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.35 Pain Relevance 0.16
These findings suggested that the midkine promoter may be a potential candidate for safe suicide gene therapy targeting pancreatic cancer.
Positive_regulation (candidate) of midkine associated with suicidal behaviour and pancreatic cancer
2) Confidence 0.26 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.83 Pain Relevance 0
These findings suggest that MK may be involved in epithelial differentiation, vascular growth and remodeling in the developing lung and is not required for regular lung maintenance.
Neg (not) Positive_regulation (required) of MK in lung
3) Confidence 0.25 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.27 Pain Relevance 0
Midkine is a heparin-binding growth factor that is induced by retinoic acid in embryonal carcinoma cells, and it may be another candidate for this purpose [11].
Positive_regulation (induced) of Midkine associated with embryonal carcinoma
4) Confidence 0.24 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 1.27 Pain Relevance 0
Lastly, we have previously shown that MK is upregulated in glucocorticoid receptor knockout mice, and that GC and RA differentially regulate MK in vitro [10].
Positive_regulation (upregulated) of MK associated with targeted disruption and rheumatoid arthritis
5) Confidence 0.23 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.75 Pain Relevance 0.13
Dexamethasone treatment had a biphasic effect, increasing MK mRNA precociously, between PN1 and PN5, and then decreasing content at PN10 and PN15.
Positive_regulation (increasing) of MK associated with dexamethasone
6) Confidence 0.23 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.23 Pain Relevance 0.23
Dexamethasone treatment delayed the increase in MK with a 3-fold reduction (p < 0.01, n = 3) compared to control animals at PN5.
Positive_regulation (increase) of MK associated with dexamethasone
7) Confidence 0.22 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.32 Pain Relevance 0.19
In control animals, MK mRNA increased between PN5 and PN10.
Positive_regulation (increased) of MK
8) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.29 Pain Relevance 0.26
Cells treated with hormones (DEX, cAMP, or DCI) had significantly decreased MK protein levels, with an apparent additive effect of GC and cAMP to repress the culture-induced increase in MK and RA eliminated the repressive effects of hormones (**p < 0.05 vs. no RA).
Positive_regulation (increase) of MK associated with rheumatoid arthritis and dexamethasone
9) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.38 Pain Relevance 0.14
These data when viewed in the context of the high levels of corneal staining reported with biguanide based MPS like ReNu MultiPlus, the recent data of Rosenthal and coworkers regarding loss of disinfectant efficacy with ReNu MultiPlus and MoistureLoc and the report of Iyer et al regarding the ongoing increase in fungal CL-MK paints a disturbing picture; one that may be only the tip of the iceberg (Dannelley et al 2004; Iyer et al 2006; Mack 2006).
Positive_regulation (increase) of CL-MK
10) Confidence 0.00 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2704532 Disease Relevance 0.34 Pain Relevance 0.06

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