INT245182

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 2.05
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TCF7L2) nucleoplasm (TCF7L2) extracellular region (SPINK1)
nucleus (TCF7L2) DNA binding (TCF7L2) transcription factor binding (TCF7L2)
SPINK1 (Homo sapiens)
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 95.80 Very High Very High Very High
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 133 100.00 Very High Very High Very High
Pancreatitis 52 100.00 Very High Very High Very High
Calcification 4 100.00 Very High Very High Very High
Clinical Trials And Case Reports 2 54.92 Quite High
Insulin Resistance 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Ketoacidosis 1 5.00 Very Low Very Low Very Low
Renal Disease 1 5.00 Very Low Very Low Very Low
Ketosis 1 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

Background

SPINK1 Binding (interact) of TCF7L2 associated with calcification, diabetes mellitus and pancreatitis
1) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Title Doc Link PMC2529279 Disease Relevance 2.05 Pain Relevance 0.10

General Comments

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