INT245183

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 6.39
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCF7L2) mitochondrion (CTSB) intracellular (CTSB)
DNA binding (TCF7L2) cytoplasm (CTSB) cell proliferation (TCF7L2)
Anatomy Link Frequency
exocrine pancreas 1
CTSB (Homo sapiens)
TCF7L2 (Homo sapiens)
CTSB - L26V (2)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 96.16 Very High Very High Very High
fibrosis 3 15.88 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 399 100.00 Very High Very High Very High
Pancreatitis 156 100.00 Very High Very High Very High
Calcification 12 100.00 Very High Very High Very High
Clinical Trials And Case Reports 6 66.08 Quite High
Cystic Fibrosis 3 15.88 Low Low
Ketosis 3 11.68 Low Low
Ketoacidosis 3 9.68 Low Low
Insulin Resistance 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Renal Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since diabetes in TCP is also thought to be due to destruction of endocrine pancreatic cells secondary to destruction of exocrine pancreas, we investigated the interaction between the TCF7L2 variants and N34S SPINK1 and L26V CTSB mutations and explored whether presence of TCF7L2 variants in patients with these mutations predisposes them to FCPD.


CTSB (L26V) Binding (interaction) of TCF7L2 in exocrine pancreas associated with diabetes mellitus and pancreatitis
1) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 2.26 Pain Relevance 0
We also investigated the interaction between the TCF7L2 variants and N34S SPINK1 and L26V CTSB mutations, since they are strong predictors of risk for TCP.


CTSB (L26V) Binding (interaction) of TCF7L2 associated with pancreatitis
2) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 2.07 Pain Relevance 0.08
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

Background

CTSB Binding (interact) of TCF7L2 associated with calcification, diabetes mellitus and pancreatitis
3) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Title Doc Link PMC2529279 Disease Relevance 2.06 Pain Relevance 0.10

General Comments

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