INT245185

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 6.88
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCF7L2) DNA binding (TCF7L2) GTPase activity (RRAD)
cell proliferation (TCF7L2) signal transduction (RRAD) plasma membrane (RRAD)
RRAD (Homo sapiens)
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 97.48 Very High Very High Very High
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 399 100.00 Very High Very High Very High
Pancreatitis 156 100.00 Very High Very High Very High
Calcification 12 100.00 Very High Very High Very High
Clinical Trials And Case Reports 6 56.60 Quite High
Autoimmune Disease 3 47.44 Quite Low
Hyperglycemia 3 44.40 Quite Low
Insulin Resistance 9 40.40 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Ketoacidosis 3 5.00 Very Low Very Low Very Low
Renal Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As TCF7L2 is a major susceptibility gene for T2D, a lack of association of TCF7L2 variants with TCP or FCPD observed in our study suggests that T2D associated TCF7L2 variants are not associated with diabetes in TCP or the diabetes in TCP patients may not be similar to T2D.
diabetes Binding (associated) of TCF7L2 associated with diabetes mellitus and pancreatitis
1) Confidence 0.00 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 2.91 Pain Relevance 0
Type 2 diabetes associated TCF7L2 variants are not associated with diabetes in TCP.
diabetes Binding (associated) of TCF7L2 associated with diabetes mellitus and pancreatitis
2) Confidence 0.00 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.88 Pain Relevance 0
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

Background

diabetes Binding (interact) of TCF7L2 associated with calcification, diabetes mellitus and pancreatitis
3) Confidence 0.00 Published 2008 Journal BMC Med Genet Section Title Doc Link PMC2529279 Disease Relevance 2.08 Pain Relevance 0.10

General Comments

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