INT24519

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.98
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERG) signal transduction (ERG) nucleus (ERG)
DNA binding (ERG) cytoplasm (ERG) signal transducer activity (ERG)
Anatomy Link Frequency
eye 2
photoreceptor 2
photoreceptor cell 1
lens 1
neuroretina 1
ERG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 145 94.28 High High
Neurotransmitter 3 89.20 High High
depression 6 88.24 High High
Neuritis 6 86.56 High High
Calcium channel 18 85.12 High High
Multiple sclerosis 2 75.00 Quite High
Glutamate 3 57.60 Quite High
anesthesia 24 50.00 Quite Low
lidocaine 4 50.00 Quite Low
tolerance 20 42.28 Quite Low
Disease Link Frequency Relevance Heat
Cyst 15 99.82 Very High Very High Very High
Optic Nerve Injuries 63 99.62 Very High Very High Very High
Injury 93 99.48 Very High Very High Very High
Retinoschisis 34 99.30 Very High Very High Very High
Aging 1 98.86 Very High Very High Very High
Targeted Disruption 30 98.48 Very High Very High Very High
Night Blindness 13 98.14 Very High Very High Very High
Gliosis 20 96.52 Very High Very High Very High
INFLAMMATION 145 94.28 High High
Apoptosis 8 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On ERG, the b wave was decreased.
Negative_regulation (decreased) of ERG
1) Confidence 0.38 Published 2006 Journal J Fr Ophtalmol Section Body Doc Link 16523160 Disease Relevance 0.08 Pain Relevance 0
The FF-ERG in 8 out of 10 patients with satisfactory recordings was diminished in the affected eye.
Negative_regulation (diminished) of ERG in eye
2) Confidence 0.12 Published 1989 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2463143 Disease Relevance 0.88 Pain Relevance 0.51
The release of trophic factors by macro and microglia activation in these injured retinas [33] may play a role in the amplitude of these waves as previously suggested [43], but it is also possible that transient down-regulation of photoreceptor-specific genes after ONT could explain the reduction of the major ERG components.
Negative_regulation (reduction) of ERG in photoreceptor associated with optic nerve injuries
3) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.55 Pain Relevance 0
The average amplitude of the scotopic ERG b-wave was reduced by 89% between 2 and 9 months of age, while the photopic ERG b-wave amplitude was decreased by 77% during the same period [2].
Negative_regulation (decreased) of ERG
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957406 Disease Relevance 0.25 Pain Relevance 0
During the aging of patients with XLRS, the size of foveal cysts and the ERG b-wave amplitudes decrease [5,10,29,30].
Negative_regulation (decrease) of ERG associated with aging, cyst and retinoschisis
5) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519029 Disease Relevance 1.38 Pain Relevance 0
Regarding the neuroretina, intracameral inoculation led to a modest and transient reduction of ERG function signified by a loss in B-wave amplitudes eight days post inoculation—a time point consistent with the identification of intracameral inflammation.
Negative_regulation (reduction) of ERG in neuroretina associated with inflammation
6) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.61 Pain Relevance 0.12
This also correlated with neuroretinal trauma evidenced by a sustained loss in ERG function, increased GFAP levels indicative of active Muller as well as astrocyte cell gliosis, and significant photoreceptor cell degeneration.
Negative_regulation (loss) of ERG in photoreceptor cell associated with injury and gliosis
7) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.09 Pain Relevance 0.15
Under scotopic conditions the positive b-wave ERG component becomes more prominent.
Negative_regulation (positive) of ERG
8) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1192803 Disease Relevance 0.22 Pain Relevance 0
B max values calculated from B-wave amplitudes (Figure 6B) verified the statistical significance of ERG reduction relative to the contralateral eye (p?
Negative_regulation (reduction) of ERG in eye
9) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.14 Pain Relevance 0.07
This indicates why ERG reductions as a consequence of intracameral inoculation proved significantly less pronounced than those for mice receiving a lens puncture wound
Negative_regulation (reductions) of ERG in lens associated with injury
10) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.43 Pain Relevance 0.11
In the neuroretina, a transient loss in ERG B-wave amplitudes was detected, but photoreceptor degeneration and GFAP upregulation were not.
Negative_regulation (loss) of ERG in photoreceptor
11) Confidence 0.02 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2276183 Disease Relevance 0.41 Pain Relevance 0.13
Lee and Flannery [43] also noted an age-related reduction in ERG amplitudes in heterozygous rhodopsin knockout mice, with the greatest relative change occurring in the a-wave.
Negative_regulation (reduction) of ERG associated with targeted disruption
12) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697457 Disease Relevance 0.16 Pain Relevance 0
The discrepancy, between retention of cone function in the optokinetic response and loss of cone signals in the ERG, may be due to differential processing of cone information or mutation-dependent changes in the retinal circuits responsible for the OKR and ERG.
Negative_regulation (loss) of ERG
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
As previously reported in Cacna1fnob2 mice, CACNA1F mutations in humans cause ERG b-wave reductions under both dark-adapted (scotopic) and light-adapted (photopic) conditions.
Negative_regulation (reductions) of ERG
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0.35 Pain Relevance 0.11
Disorders of synaptic transmission are thought to be instrumental in two forms of human X-linked congenital stationary night blindness (CSNB): the “incomplete” form (iCSNB, or CSNB2), in which rod- and cone-driven electroretinogram (ERG) responses are reduced in amplitude, but oscillatory potentials (OPs) can be recorded; and the “complete” form (cCSNB, or CSNB1), in which rod-driven ERG responses are greatly reduced or absent but cone-driven responses are relatively well preserved, and OPs are rarely recorded.
Negative_regulation (reduced) of ERG associated with night blindness
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0.42 Pain Relevance 0.12

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