INT245190

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 12.29
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TCF7L2) nucleoplasm (TCF7L2) nucleus (TCF7L2)
DNA binding (TCF7L2) transcription factor binding (TCF7L2)
Anatomy Link Frequency
body 1
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 9 98.20 Very High Very High Very High
Pain 6 85.68 High High
fibrosis 6 25.96 Quite Low
Chronic pancreatitis 6 25.00 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 901 99.72 Very High Very High Very High
Pancreatitis 312 99.54 Very High Very High Very High
Impaired Glucose Tolerance 9 98.52 Very High Very High Very High
Obesity 9 98.44 Very High Very High Very High
Insulin Resistance 18 94.00 High High
Disorder Of Lipid Metabolism 1 88.48 High High
Pain 6 85.68 High High
Hyperglycemia 6 79.60 Quite High
Calcification 24 75.00 Quite High
Autoimmune Disease 6 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we also analyzed the association of TCF7L2 variants in the entire cohort irrespective of their diabetic status.
TCF7L2 Spec (analyzed) Binding (association) of associated with diabetes mellitus
1) Confidence 0.48 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 1.83 Pain Relevance 0.09
We and others have earlier replicated the strong association of TCF7L2 variants with T2D in Indian population and provided evidence of its likely role in the pathogenesis of T2D by influencing both insulin secretion and insulin resistance [20].
TCF7L2 Binding (association) of associated with diabetes mellitus and insulin resistance
2) Confidence 0.37 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 1.51 Pain Relevance 0
Allele and genotypic frequencies did not differ significantly, between TCP patients and controls, FCPD patients and controls and between TCP and FCPD patients, suggesting lack of statistically significant association of TCF7L2 polymorphisms with FCPD (table 3).
TCF7L2 Binding (association) of associated with diabetes mellitus and pancreatitis
3) Confidence 0.37 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 1.20 Pain Relevance 0
In line with previous reports, FTO rs1421085 was associated with body mass index (P<0.001).30 CDC123/CAMK10 rs10811661 (P=0.001), KCNJ11 rs5219 (P<0.01), and TCF7L2 rs7901695 (P<0.002) were associated with two hour glucose after an oral glucose tolerance test.
TCF7L2 Binding (associated) of in body associated with obesity, tolerance and impaired glucose tolerance
4) Confidence 0.36 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2806945 Disease Relevance 0.54 Pain Relevance 0.05
Since there is debate about the type of diabetes in TCP and FCPD, the lack of association with TCF7L2, the gene most strongly associated with T2D may suggest that the diabetes in TCP patients does not have similar features as T2D.


TCF7L2 Binding (association) of associated with diabetes mellitus and pancreatitis
5) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 3.14 Pain Relevance 0
Our data also suggests that co-existence of TCF7L2 variants and the SPINK1 and CTSB mutations, that predict susceptibility to exocrine damage, may interact to determine the onset of diabetes in TCP patients.



TCF7L2 Binding (interact) of associated with diabetes mellitus and pancreatitis
6) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.73 Pain Relevance 0
We hypothesized that we would observe an association of variants in the TCF7L2 gene with FCPD, if diabetes in these patients is T2D.
TCF7L2 Binding (association) of associated with diabetes mellitus
7) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 2.34 Pain Relevance 0

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