INT245191

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.54
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TCF7L2) nucleoplasm (TCF7L2) nucleus (TCF7L2)
DNA binding (TCF7L2) transcription factor binding (TCF7L2)
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 71.12 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 177 100.00 Very High Very High Very High
Pancreatitis 52 81.92 Quite High
Ocular Toxicity (including Many Sub-types) 2 71.80 Quite High
Cv General 3 Under Development 1 71.12 Quite High
Renal Failure 1 70.80 Quite High
Myocardial Infarction 2 70.20 Quite High
Stroke 1 69.60 Quite High
Disease 5 66.40 Quite High
Obesity 6 56.76 Quite High
Abdominal Obesity 1 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primers, amplifying segments of TCF7L2 gene harboring SNPs rs7903146 and rs12255372 were adopted from our earlier study [20].
Positive_regulation (segments) of TCF7L2
1) Confidence 0.46 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 0.33 Pain Relevance 0
However, substantial advances have been made in the past few years, with an increase in confirmed type 2 diabetes susceptibility loci from 3 genes (PPARG, KCNJ11, and TCF7L2) to almost 20 (with newly identified variants in the following genes: ADAMTS9, CDKAL1, CDKN2A/B, CAMK1D, FTO, HHEX/IDE, HNF1B, IGF2BP2, JAZF1, MTNR1B, NOTCH2, SLC30A8, THADA, TSPAN8, and WFS1) (14–17).
Positive_regulation (increase) of TCF7L2 associated with diabetes mellitus
2) Confidence 0.37 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 1.21 Pain Relevance 0.07

General Comments

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