INT245196

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.83
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD209) cell adhesion (CD209) plasma membrane (CD209)
intracellular (CD209) cytoplasm (CD209)
Anatomy Link Frequency
endothelial cells 1
dendritic cells 1
CD209 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 99.48 Very High Very High Very High
alcohol 4 76.00 Quite High
cytokine 12 59.04 Quite High
depression 40 58.20 Quite High
dexamethasone 3 45.12 Quite Low
cINOD 3 32.72 Quite Low
tolerance 12 5.00 Very Low Very Low Very Low
antidepressant 7 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 58 100.00 Very High Very High Very High
Adhesions 25 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 252 99.84 Very High Very High Very High
INFLAMMATION 9 99.48 Very High Very High Very High
Cancer 6 99.28 Very High Very High Very High
Necrosis 10 99.04 Very High Very High Very High
Disease 44 97.16 Very High Very High Very High
Congenital Anomalies 15 96.24 Very High Very High Very High
Diabetes Mellitus 40 93.04 High High
Insulin Resistance 9 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found downregulation of an additional CTLR, DC-SIGN, indicating a more global defect in expression of members of this family.
Negative_regulation (downregulation) of DC-SIGN
1) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.86 Pain Relevance 0
Lupus dendritic cells display decreased DC-SIGN, but present normal CR3 and Fc?
Negative_regulation (decreased) of DC-SIGN in dendritic cells associated with systemic lupus erythematosus
2) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.02 Pain Relevance 0.06
The CTLR DC-SIGN, however, was also downregulated in SLE moDCs – both before and after stimulation (unstimulated percentage expression: control (n = 30), 71.3 ± 3.5 and SLE (n = 52), 53.2 ± 3.7; P = 0.005; stimulated percentage expression: control (n = 21), 64.7 ± 6.0 and SLE (n = 39), 48.6 ± 4.5; P = 0.03; Figure 5).
Negative_regulation (downregulated) of DC-SIGN associated with systemic lupus erythematosus
3) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.10 Pain Relevance 0
For example, the eleven Sydney-based GPs interviewed represent more than one third of the total number of s100 HIV prescriber GPs working in the inner suburbs of Sydney.
Negative_regulation (number) of s100 HIV associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.01 Published 2008 Journal BMC Fam Pract Section Body Doc Link PMC2529282 Disease Relevance 0.48 Pain Relevance 0.10
NO produced by endothelial cells also has anti-inflammatory effects, which include a decrease in soluble vascular cell and intercellular adhesion molecules-1, E-selectin, and tumor necrosis factor ?
Negative_regulation (decrease) of molecules-1 in endothelial cells associated with necrosis, inflammation, cancer and adhesions
5) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 1.38 Pain Relevance 0.05

General Comments

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